Unravelling drug-induced hypertension: Molecular mechanisms of aldosterone-independent mineralocorticoid receptor activation by posaconazole

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dc.contributor.author Sánchez-Niño, María Dolores
dc.contributor.author Ortiz, Alberto
dc.contributor.other UAM. Departamento de Medicina es_ES
dc.contributor.other Instituto de Investigaciones Biomédicas "Alberto Sols" (IIBM) es_ES
dc.date.accessioned 2018-12-20T12:37:17Z
dc.date.available 2018-12-20T12:37:17Z
dc.date.issued 2018-10-01
dc.identifier.citation Clinical Kidney Journal 11.5 (2018): 688–690 en_US
dc.identifier.issn 2048-8505 (print) es_ES
dc.identifier.issn 2048-8513 (online) es_ES
dc.identifier.uri http://hdl.handle.net/10486/686114
dc.description.abstract Drug-induced hypertension offers the opportunity to further understand pathways involved in the regulation of blood pressure. Posaconazole is an antifungal agent known to induce hypertension and hypokalaemia. In recent months, a flurry of reports has unravelled the metabolic processes involved. In this issue of CKJ, Barton K, Davis TK, Marshall B et al. Posaconazole-induced hypertension and hypokalemia due to inhibition of the 11β-hydroxylase enzyme. Clin Kidney J 2018; 11: 691-693 present convincing evidence of 11β-hydroxylase inhibition resulting in a biochemical syndrome resembling genetic congenital adrenal hyperplasia and characterized by high 11-deoxycorticosterone and 11-deoxycortisol levels as well as androgen levels. This adds to prior evidence supporting inhibition of 11β-hydroxysteroid dehydrogenase 2, the enzyme that inactivates cortisol in aldosterone-sensitive tissues such as the kidneys, yielding a syndrome resembling genetic apparent mineralocorticoid excess or licorice toxicity, characterized by a high cortisol/cortisone ratio en_US
dc.description.sponsorship The authors were supported by FIS PI16/02057, PI18/01366, ISCIII-RETIC REDinREN RD016/0009 Fondos FEDER, Sociedad Española de Nefrología, Comunidad de Madrid B2017/BMD-3686 CIFRA2-CM, Miguel Servet MS14/00133 to M.D.S.-N. en_US
dc.format.extent 3 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Oxford University Press on behalf of ERA-EDTA en_US
dc.relation.ispartof Clinical Kidney Journal en_US
dc.rights © The Author(s) 2018 en_US
dc.subject.other 11-deoxycortisol en_US
dc.subject.other 11b-hydroxylase en_US
dc.subject.other 11b-hydroxysteroid dehydrogenase 2 en_US
dc.subject.other Antifungal en_US
dc.subject.other Drug-induced hypertension en_US
dc.title Unravelling drug-induced hypertension: Molecular mechanisms of aldosterone-independent mineralocorticoid receptor activation by posaconazole en_US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion https://doi.org/10.1093/ckj/sfy087 es_ES
dc.identifier.doi 10.1093/ckj/sfy087 es_ES
dc.identifier.publicationfirstpage 686 es_ES
dc.identifier.publicationissue 5 es_ES
dc.identifier.publicationlastpage 690 es_ES
dc.identifier.publicationvolume 11 es_ES
dc.relation.projectID Gobierno de España. FIS PI16/02057 es_ES
dc.relation.projectID Gobierno de España. PI18/01366 es_ES
dc.relation.projectID Gobierno de España. RD016/0009 es_ES
dc.relation.projectID Comunidad de Madrid. B2017/BMD-3686/CIFRA2 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.cc Reconocimiento – NoComercial es_ES
dc.rights.accessRights openAccess en

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