Clinical and molecular comparative study of colorectal cancer based on age-of-onset and tumor location: Two main criteria for subclassifying colorectal cancer

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Show simple item record Álvaro, Edurne Cano, Juana M. García, Juan L. Brandáriz, Lorena Olmedillas-López, Susana Arriba, María Rueda, Daniel Rodríguez, Yolanda Cañete, Ángel Arribas, Julia Inglada-Pérez, Lucía Pérez, Jessica Gómez, Carlos García-Arranz, Mariano García-Olmo, Damián Goel, Ajay Urioste, Miguel González-Sarmiento, Rogelio Perea, José
dc.contributor.other UAM. Departamento de Cirugía es_ES
dc.contributor.other Instituto de Investigación Sanitaria Fundación Jiménez Díaz (ISS-FJD) es_ES 2019-10-25T16:06:55Z 2019-10-25T16:06:55Z 2019-02-22
dc.identifier.citation International Journal of Molecular Sciences 20.4 (2019): 968 en_US
dc.identifier.issn 1661-6596 (print) es_ES
dc.identifier.issn 1422-00678 (online) es_ES
dc.description.abstract Our aim was to characterize and validate that the location and age of onset of the tumor are both important criteria to classify colorectal cancer (CRC). We analyzed clinical and molecular characteristics of early-onset CRC (EOCRC) and late-onset CRC (LOCRC), and we compared each tumor location between both ages-of-onset. In right-sided colon tumors, early-onset cases showed extensive Lynch syndrome (LS) features, with a relatively low frequency of chromosomal instability (CIN), but a high CpG island methylation phenotype. Nevertheless, late-onset cases showed predominantly sporadic features and microsatellite instability cases due to BRAF mutations. In left colon cancers, the most reliable clinical features were the tendency to develop polyps as well as multiple primary CRC associated with the late-onset subset. Apart from the higher degree of CIN in left-sided early-onset cancers, differential copy number alterations were also observed. Differences among rectal cancers showed that early-onset rectal cancers were diagnosed at later stages, had less association with polyps, and more than half of them were associated with a familial LS component. Stratifying CRC according to both location and age-of-onset criteria is meaningful, not only because it correlates the resulting categories with certain molecular bases, but with the confirmation across larger studies, new therapeutical algorithms could be defined according to this subclassification. en_US
dc.description.sponsorship This work was funded by Project PI10/0683 and PI13/0127 and PI16/01650 to J.P, and PI16/01920 to R.G.S, and PI17/01233 to D.G-O from the Spanish Ministry of Health and Consumer Affairs, and co-funded by the European Regional Development Fund (FEDER); and supported by grants R01 CA72851, CA18172, CA184792, and U01 CA187956 from the National Cancer Institute, National Institutes of Health to Ajay Goel es_ES
dc.format.extent 16 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher MDPI, Basel, Switzerland en_US
dc.relation.ispartof International Journal of Molecular Sciences en_US
dc.rights © 2019 by the authors en_US
dc.subject.other Chromosomal instability en_US
dc.subject.other CpG island methylator phenotype en_US
dc.subject.other Early-onset colorectal cancer en_US
dc.subject.other Late-onset colorectal cancer en_US
dc.subject.other Microsatellite instability en_US
dc.subject.other Tumor location en_US
dc.title Clinical and molecular comparative study of colorectal cancer based on age-of-onset and tumor location: Two main criteria for subclassifying colorectal cancer en_US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion es_ES
dc.identifier.doi 10.3390/ijms20040968 es_ES
dc.identifier.publicationfirstpage 968-1 es_ES
dc.identifier.publicationissue 4 es_ES
dc.identifier.publicationlastpage 968-16 es_ES
dc.identifier.publicationvolume 20 es_ES
dc.relation.projectID Gobierno de España. PI17/01233 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en Reconocimiento es_ES
dc.rights.accessRights openAccess en
dc.authorUAM García Arranz, Mariano Andrés (262199)
dc.authorUAM García Olmo, Damián (259813)

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