Insulin sensor based on nanoparticle-decorated multiwalled carbon nanotubes modified electrodes

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dc.contributor.author Martínez-Periñán, Emiliano
dc.contributor.author Revenga-Parra, Mónica
dc.contributor.author Gennari, Marcello
dc.contributor.author Pariente, Félix
dc.contributor.author Mas-Ballesté, Rubén
dc.contributor.author Zamora, Félix
dc.contributor.author Lorenzo, Encarnación
dc.contributor.other UAM. Departamento de Química Analítica y Análisis Instrumental es_ES
dc.contributor.other UAM. Departamento de Química Inorgánica es_ES
dc.date.accessioned 2019-12-13T11:45:13Z
dc.date.available 2019-12-13T11:45:13Z
dc.date.issued 2016-01-01
dc.identifier.citation Sensors and Actuators, B: Chemical 222 (2016): 331-338 en_US
dc.identifier.issn 0925-4005 (print) en_US
dc.identifier.issn 1873-3077 (online) en_US
dc.identifier.uri http://hdl.handle.net/10486/689574
dc.description.abstract Insulin sensors based on glassy carbon electrodes modified with nafion-multiwalled carbon nanotubes decorated with nickel hydroxide nanoparticles (Ni(OH)<inf>2</inf>NPs/Nafion-MWCNTs/GC), were prepared by electrochemical deposition of Ni(OH)<inf>2</inf>NPs from a dinuclear paddle-wheel Ni monothiocarboxylate complex on the MWCNTs/GC surface. The size and distribution of the Ni(OH)<inf>2</inf>NPs/Nafion-MWCNTs were characterized by transmission electron microscopy (TEM). The results show that Ni(OH)<inf>2</inf> nanoparticles were electrodeposited on the surface of carbon nanotubes. Moreover, the electrochemical behavior of the modified electrodes in aqueous alkaline solutions of insulin was studied by cyclic voltammetry and chronoamperometry. It was found that the as-prepared nanoparticles have excellent electrocatalytic activity towards insulin oxidation due to their special properties, reducing the overpotential and improving the electrochemical behavior, compared to the bare GC electrode. Amperometry was used to evaluate the analytical performance of modified electrode in the determination of insulin. Excellent analytical features, including high sensitivity (5.0 A mol cm<sup>-2</sup> μM<sup>-1</sup>), low detection limit (85 nM) and wide dynamic range (up to 10.00 μM), were achieved under optimum conditions. Moreover, these insulin sensors show good repeatability and a high stability after successive potential cycling. Common substances such as ascorbic acid, uric acid and acetaminophen do not interfere. Finally, the developed sensors have been applied to the determination of insulin in pharmaceuticals and in human plasma. Efficient recoveries for pharmaceuticals and human plasma demonstrate that the proposed methodology can be satisfactorily applied to these types of samples en_US
dc.description.sponsorship The authors acknowledge Ministerio de Economía y Competitividad (project No. CTQ2014-53334-C2-1-R and MAT2013-46753-C2-1-P) and Comunidad de Madrid (NANOAVANSENS Program) for financial support. E.M.P. gratefully acknowledges the FPU-2010 Grant from the Ministerio de Educación en_US
dc.format.extent 29 pag. en_US
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Elsevier B.V en_US
dc.relation.ispartof Sensors and Actuators, B: Chemical en_US
dc.rights © 2015 Elsevier B.V. es_ES
dc.subject.other Dinickel complexes en_US
dc.subject.other Insulin electrocatalysis en_US
dc.subject.other Nickel hydroxide nanoparticles en_US
dc.subject.other Paddle-wheel complexes en_US
dc.title Insulin sensor based on nanoparticle-decorated multiwalled carbon nanotubes modified electrodes en_US
dc.type article en
dc.subject.eciencia Química es_ES
dc.date.embargoend 2018-01-01
dc.relation.publisherversion https://doi.org/10.1016/j.snb.2015.08.033 es_ES
dc.identifier.doi 10.1016/j.snb.2015.08.033 es_ES
dc.identifier.publicationfirstpage 331 es_ES
dc.identifier.publicationlastpage 338 es_ES
dc.identifier.publicationvolume 222 es_ES
dc.relation.projectID Gobierno de España. CTQ2014-53334-C2-1-R es_ES
dc.relation.projectID Gobierno de España. MAT2013-46753-C2-1-P es_ES
dc.relation.projectID Comunidad de Madrid. S2013/MIT-3029/NANOAVANSENS es_ES
dc.type.version info:eu-repo/semantics/acceptedVersion en
dc.rights.cc Reconocimiento – NoComercial – SinObraDerivada es_ES
dc.rights.accessRights openAccess en
dc.authorUAM Martínez Periñán, Emiliano (264721)
dc.authorUAM Revenga Parra, Monica (261542)
dc.authorUAM Pariente Alonso, Félix (259254)
dc.authorUAM Mas Balleste, Rubén (261764)
dc.authorUAM Zamora Abanades, Félix Juan (258846)
dc.authorUAM Lorenzo Abad, Encarnación (261505)


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