dc.contributor.author | Brandariz, Lorena | |
dc.contributor.author | Arriba, María | |
dc.contributor.author | García, Juan Luis | |
dc.contributor.author | Cano, Juana María | |
dc.contributor.author | Rueda, Daniel | |
dc.contributor.author | Rubio, Eduardo | |
dc.contributor.author | Rodríguez, Yolanda | |
dc.contributor.author | Pérez, Jessica | |
dc.contributor.author | Vivas, Alfredo | |
dc.contributor.author | Sánchez, Carmen | |
dc.contributor.author | Tapial, Sandra | |
dc.contributor.author | Pena, Laura | |
dc.contributor.author | García Arranz, Mariano Andrés | |
dc.contributor.author | García Olmo, Damián | |
dc.contributor.author | Urioste, Miguel | |
dc.contributor.author | González-Sarmiento, Rogelio | |
dc.contributor.author | Perea, José | |
dc.contributor.other | UAM. Departamento de Cirugía | es_ES |
dc.contributor.other | Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ) | es_ES |
dc.contributor.other | Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD) | es_ES |
dc.date.accessioned | 2018-09-27T14:43:49Z | |
dc.date.available | 2018-09-27T14:43:49Z | |
dc.date.issued | 2018-01-01 | |
dc.identifier.citation | Oncotarget 9.20 (2018): 15302-15311 | en_US |
dc.identifier.issn | 1949-2553 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10486/685204 | |
dc.description.abstract | Background: Since there is a predilection of some clinical and molecular features
for a given tumor location, we assessed whether this can be confirmed in late-onset
colorectal cancer (LOCRC).
Results: Right colon cancers showed features associated with sporadic
Microsatellite Instability: predominance of female cases and BRAF mutations, and
an important mucinous component. Left colon cancers developed a higher number
of polyps and multiple primary CRCs, showed the strongest familial component, and
had better prognosis. Rectal cancers showed a predominantly sporadic phenotype,
with worse prognosis and a CpG Island Methylator Phenotype (CIMP)-High. No copy
number alterations (CNAs) greater than or equal to 50% were observed in this
LOCRC group, and the most recurrent alterations were losses at 5q13 and 14q11,
and gains at 7q11, 7q21-q22, 19p13-p12, 19q13 and 20p11-q11. KRAS and PIK3CA
were the only mutated genes showing differences according to the tumor location,
mainly for right colon cancers.
Materials and Methods: We analyzed clinical and molecular characteristics of
LOCRC at different tumor locations in order to determine if there are differential
phenotypes related with the location in the colon.
Conclusions: Categorizing LOCRC according to tumor location appears to be an
adequate first step to resolving the heterogeneity of this subset of CRC | en_US |
dc.description.sponsorship | This work was funded by Projects PI10/0683, PI13/01741, PI13/0127 and PI14/00459 from the Spanish Ministry of Health and Consumer Affairs and FEDER, and was approved by the Ethics Committee of our Institution | en_US |
dc.format.extent | 10 pag. | es_ES |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | Impact Journals | en_US |
dc.relation.ispartof | Oncotarget | en_US |
dc.rights | © Brandariz et al | es_ES |
dc.subject.other | Chromosomal instability | en_US |
dc.subject.other | Colon location | en_US |
dc.subject.other | CpG island methylator phenotype | en_US |
dc.subject.other | Late-onset colorectal cancer | en_US |
dc.subject.other | Microsatellite instability | en_US |
dc.title | Differential clinicopathological and molecular features within late-onset colorectal cancer according to tumor location | en |
dc.type | article | en |
dc.subject.eciencia | Medicina | es_ES |
dc.relation.publisherversion | https://doi.org/10.18632/oncotarget.24502 | es_ES |
dc.identifier.doi | 10.18632/oncotarget.24502 | es_ES |
dc.identifier.publicationfirstpage | 15302 | es_ES |
dc.identifier.publicationissue | 20 | es_ES |
dc.identifier.publicationlastpage | 15311 | es_ES |
dc.identifier.publicationvolume | 9 | es_ES |
dc.relation.projectID | Gobierno de España. PI10/0683 | es_ES |
dc.relation.projectID | Gobierno de España. PI13/0127 | es_ES |
dc.relation.projectID | Gobierno de España. PI13/0127 | es_ES |
dc.relation.projectID | Gobierno de España. PI14/00459 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.rights.cc | Reconocimiento | es_ES |
dc.rights.accessRights | openAccess | en |
dc.facultadUAM | Facultad de Medicina | |
dc.institutoUAM | Instituto de Investigación Sanitaria Fundación Jiménez Díaz (ISS-FJD) | |
dc.institutoUAM | Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ) | |