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  • Item type: Publication ,
    Computerized assessment of handwriting in de novo Parkinson's disease: A kinematic study
    (Elsevier, 2024-08-01) Díaz Feliz, Lola; Sanz Cartagena, Pilar; Faundez Zanuy, Marcos; Arbelo González, José; García Ruiz-Espiga, Pedro José; Departamento de Medicina; Facultad de Medicina
    Introduction Dysgraphia, a recognized PD motor symptom, lacks effective clinical assessment. Current evaluation relies on motor assessment scales. Computational methods introduced over the past decade offer an objective dysgraphia assessment, considering size, duration, speed, and handwriting fluency. Objective evaluation of dysgraphia may be of help for early diagnosis of PD. Objective Computerized assessment of dysgraphia in de novo PD patients and its correlation with clinical scales. Methods We evaluated 38 recently diagnosed, premedication PD patients and age-matched controls without neurological disorders. Participants wrote “La casa de Pamplona es bonita” three times on paper and once on a Wacom tablet under the paper, totaling four phrases. Writing segments of 5–10 s were analyzed. The Wacom tablet captured kinematic data, including mean velocity, mean acceleration, and pen pressure. Data were saved in.svc format and analyzed using specialized software developed by Tecnocampus Mataró. Standard clinical practice data, Hoehn & Yahr staging, and UPDRS scales were used for evaluation. Results Significant kinematic differences existed; patients had lower mean speed (27 ± 12 vs. 48 ± 18, p < 0.0001) and mean acceleration (7.2 ± 3.9 vs. 15.01 ± 7, p < 0.0001) than controls. Mean speed and mean acceleration correlated significantly with UPDRS III scores (speed: r = −0.52, p < 0.0007; acceleration: r = 0.60, p < 0.0001), indicating kinematic parameters' potential in PD evaluation. Conclusions Dysgraphia is identifiable in PD patients, even de novo, indicating an early symptom and correlates with clinical scales, offering potential for objective PD patient evaluation
  • Item type: Publication ,
    Synbiotic administration improves systemic and vascular alterations in rats with experimental microsurgical extrahepatic cholestasis: role of perivascular mesenteric innervation
    (Elsevier, 2025-10-21) Méndez-Albiñana, Pablo; Cros-Brunsó, Laia; Rodrigues-Díez, Raquel; Rodríguez-Rodríguez, Pilar; Santamaría Solís, Luis; Muñoz Labrador, Ana; Requena Rolanía, Teresa; Casani, Laura; Caballero Díaz, Francisco Félix; Prieto Nieto, María Isabel; Villamiel Guerra, María del Mar; Blanco Rivero, Javier; Gobierno de España; Departamento de Fisiología; Departamento de Anatomía, Histología y Neurociencia; Departamento de Medicina Preventiva y Salud Pública y Microbiología; Facultad de Medicina
    Liver cholestasis is marked by bile acid accumulation in the liver, along with renal issues, portal hypertension, and altered circulation. Previous studies suggest that synbiotics may improve systemic and hemodynamic conditions in liver diseases. This study investigated the effects of a commercial synbiotic on gut microbiota, liver and kidney function, and vascular changes in a cholestatic rat model, focusing on nerve functions in the superior mesenteric arteries. Adult male Wistar rats were divided into three groups: Sham-operated, Cholestatic, and Cholestatic supplemented with a synbiotic for 3 weeks, following an initial 3-week postsurgical recovery period for model establishment. The synbiotic did not significantly alter gut microbiota composition, but reduced endotoxemia and increased butyric, acetic, and propionic acid levels. It improved, but did not fully reverse, liver and renal damage. In the synbiotic group, systolic blood pressure normalized to values similar to sham-operated animals, and mesenteric artery vasoconstriction increased in response to electric field stimulation. Although the vasomotor response to noradrenaline (NA) remained unchanged, NA release was higher (P <0.05), indicating increased sympathetic activity due to symbiotic administration. Nitric oxide (NO) response did not change, but neuronal nitric oxide synthase (nNOS) expression and NO release increased after symbiotic supplementation (P <0.05). Additionally, calcitonin gene-related peptide (CGRP) levels and function were reduced by synbiotics to control values (P <0.05). In conclusion, synbiotic administration improved systemic, hepatic, renal, and vascular alterations associated with cholestasis in rats, suggesting that microbiota-directed therapies may represent a promising approach to mitigate complications of liver disease
  • Item type: Publication ,
    Effect of Christmas holidays on type 1 diabetes mellitus in users of glucose flash systems
    (Elsevier, 2024-02-01) Sebastián Valles, Fernando; Arranz Martín, José Alfonso; Martínez Alfonso, Julia; Jiménez Díaz, Jessica; Hernando Alday, Íñigo; Navas Moreno, Víctor; Armenta Joya, Teresa; Fandiño García, María del Mar; Román Gómez, Gisela Liz; Garai Hierro, Jon; Lander Lobariñas, Luis Eduardo; Martínez de Icaya, Purificación; Sampedro Núñez, Miguel Antonio; Martínez Vizcaíno, Vicente; Marazuela Azpiroz, Mónica; Departamento de Medicina; Facultad de Medicina
    Objective Christmas holidays can impact weight and glycemic control in type 2 diabetes, but their effect on type 1 diabetes (T1D) remains understudied. This study assessed how Christmas holidays affect individuals with T1D who use flash continuous glucose monitoring systems. Methods This retrospective study involved 812 adults diagnosed with T1D recruited from 3 hospitals. Clinical, anthropometric, and socioeconomic data were collected. Glucose metrics from 14 days before January 1st, and before December 1st and February 1st as control periods, were recorded. Analyses adjusted for multiple variables were conducted to assess the holiday season's impact on glycemic control. Results The average time in range during the holidays (60.0 ± 17.2%) was lower compared to December (61.9 ± 17.2%, P < .001) and February (61.7 ± 17.7%, P < .001). Time above range (TAR > 180 mg/dL) was higher during Christmas (35.8 ± 18.2%) compared to December (34.1 ± 18.3%, P < .001) and February (34.2 ± 18.4%, P < .001). Differences were also observed in TAR >250 mg/dL, coefficient of variation, and average glucose (P < .05). No differences were found in time below range or other metrics. Linear regression models showed that the holidays reduced time in range by 1.9% (β = −1.92, P = .005) and increased TAR >180 mg/dL by 1.8% (β = 1.75, P = .016). Conclusion Christmas holidays are associated with a mild and reversible deterioration in glucose metrics among individuals with T1D using flash continuous glucose monitoring, irrespective of additional influencing factors. These discoveries can be useful to advise individuals with diabetes during the festive season and to recognize potential biases within studies conducted during this timeframe
  • Item type: Publication ,
    Problemas actuales de la coordinación financiera en el Estado autonómico
    (Centro de Estudios Políticos y Constitucionales, 2025-12-02) Martínez Sánchez, César; Agencia Estatal de Investigación; Facultad de Derecho; Departamento de Derecho Público y Filosofía Jurídica
    El presente trabajo tiene como punto de partida la muy relevante descentralización financiera que ha supuesto el desarrollo del Estado autonómico en España. Tras abordar el concepto y la justificación de la coordinación financiera en España, se analizan específicamente dos problemas: la coordinación en materia de tributos cedidos y la coordinación para asegurar el cumplimiento de las reglas fiscales. El autor concluye argumentando sus dudas acerca de la constitucionalidad de alguna de las medidas adoptadas por el Estado en el ejercicio de su competencia para la coordinación financiera
  • Item type: Publication ,
    Distribution of repetitive DNAs and the hybrid origin of the red vizcacha rat (Octodontidae)
    (Canadian Science Publishing, 2012-01-24) Suárez-Villota, E.Y.; Vargas, R.A.; Marchant, C.L.; Torres, J.E.; Köhler, N.; Núñez, J.J.; Fuente Pita, Roberto de la; Page Utrilla, Jesús; Gallardo, M.H.; Agencia Estatal de Investigación; Facultad de Ciencias; Departamento de Biología
    Great genome size (GS) variations described in desert-specialist octodontid rodents include diploid species (Octomys mimax and Octodontomys gliroides) and putative tetraploid species (Tympanoctomys barrerae and Pipanacoctomys aureus). Because of its high DNA content, elevated chromosome number, and gigas effect, the genome of T. barrerae is claimed to have resulted from tetraploidy. Alternatively, the origin of its GS has been attributed to the accumulation of repetitive sequences. To better characterize the extent and origin of these repetitive DNA, self-genomic in situ hybridization (self-GISH), whole-comparative genomic hybridization (W-CGH), and conventional GISH were conducted in mitotic and meiotic chromosomes. Self-GISH on T. barrerae mitotic plates together with comparative self-GISH (using its closest relatives) discriminate a pericentromeric and a telomeric DNA fraction. As most of the repetitive sequences are pericentromeric, it seems that the large GS of T. barrerae is not due to highly repeated sequences accumulated along chromosomes arms. W-CGH using red-labeled P. aureus DNA and green-labeled O. mimax DNA simultaneously on chromosomes of T. barrerae revealed a yellow-orange fluorescence over a repetitive fraction of the karyotype. However, distinctive red-only fluorescent signals were also detected at some centromeres and telomeres, indicating closer homology with the DNA sequences of P. aureus. Conventional GISH using an excess of blocking DNA from either P. aureus or O. mimax labeled only a fraction of the T. barrerae genome, indicating its double genome composition. These data point to a hybrid nature of the T. barrerae karyotype, suggesting a hybridization event in the origin of this species
  • Item type: Publication ,
    Assessment of the public tools used to promote R&D investment in spanish SMEs
    (Springer, 2014-03-26) Romero Jordán, Desiderio; Delgado Rodríguez, María Jesús; Álvarez Ayuso, Inmaculada; Lucas Santos, Sonia de; Departamento de Análisis Económico: Teoría Económica e Historia Económica; Facultad de Ciencias Económicas y Empresariales
    In this paper, we identify the potential determinants of firm R&D to understand the effectiveness of public policies. Our results suggest a considerably low impact of tax credits and public grants on the R&D investment of the Spanish manufacturing firms. Tax credits are mainly considered by large firms that use them as a reduction in the tax burden in the corporate tax, while SMEs use public grants to alleviate financial constraints. This evidence leads to discuss alternatives to the current design of the public policies analyzed
  • Item type: Publication ,
    Equitable access, lasting results: The influence of socioeconomic environment on bariatric surgery outcomes
    (Springer Nature, 2024-10-28) Sager La Ganga, Carolina; García Sanz, Íñigo; Carrillo López, Elena; Navas Moreno, Víctor; Marazuela Azpiroz, Mónica; Gancedo Quintana, Álvaro; Marín Campos, Cristina; Carraro, Raffaele; Sebastián Valles, Fernando; Departamento de Cirugía; Departamento de Medicina; Facultad de Medicina
    Purpose Low socioeconomic status (SES) correlates with higher obesity rates and challenges in accessing treatments like bariatric surgery (BS). This study aims to assess SES’s influence on medium-term BS outcomes in a setting of universal healthcare, ensuring equitable treatment access. Material and Methods We conducted a retrospective analysis of 193 BS patients (1997–2018) at a tertiary care hospital. Weight loss was expressed as change in % total weight loss (%TWL) and excess body weight (EBW) loss. Successful BS was defined as > 50% EBW loss. SES was gauged using quartiles of the Spanish Deprivation Index. A multivariable Cox regression model evaluated SES impact on BS success over follow-up. Results The mean follow-up was 6.9 ± 4.6 years; patients averaged 43.9 ± 11.8 years, with 29.7% men. Preoperative BMI was 48.2 ± 8.2 kg/m2. At follow-up, BMI was 33.9 ± 6.6 kg/m2, with 29.3 ± 12.02% of %TWL. No SES quartile differences in BS success were noted at follow-up (log rank p = 0.960). Cox regression revealed no SES disparities in BS outcomes post-adjustment. However, female sex (HR 1.903; p = 0.009) and diabetes mellitus (HR = 0.504; p = 0.010) correlated with weight-related outcomes. Conclusion In a universal healthcare system with equitable treatment access, medium-term BS outcomes remain consistent irrespective of patients’ socioeconomic status
  • Item type: Publication ,
    Outcomes of wildlife rehabilitation vary by causes of admission for birds and mammals affected by human-wildlife impacts in southeastern Brazil
    (Elsevier, 2025-10-01) Alencar-Silva, Thaís P.; Adania, Cristina H.; Paulino, Jéssica S.; Silva, Jean C.R.; Hilário, Renato R.; Mustin, Karen; Rosalino, Luís M.; Mustin Carvalho, William Douglas; Departamento de Ecología; Facultad de Ciencias
    Wildlife Rehabilitation Centres are essential for the care, recovery and potential release of wild animals, while also providing valuable information on the impacts of human activities on biodiversity. In this study, we analyzed 12 years of data (2012 to 2023) from the Wildlife Rehabilitation Centre of Associaç˜ ao Mata Ciliar (CRAS-AMC), located in southeastern Brazil. We investigated the monthly variation in the admission of birds and mammals, identified the main causes of admission, and evaluated how these factors influence the outcomes for the animals, including death, permanent captivity or release. A total of 23,441 bird records representing 329 species and 12,395 mammal records from 73 species were analysed. Among birds, the most common causes of admission were illegal trade and removal requests usually made by members of the public in relation to animals in urban areas, with or without injuries, while mammals were most often admitted due to requested removal from urban areas, dog attacks or vehicle collisions. Mortality was the predominant outcome for both birds and mammals, though outcomes varied according to cause, with higher mortality among animals admitted due to collision with vehicle or trafficking, and higher chances of release among those with minor injuries or mistakenly removed from the wild. These findings demonstrate the importance of long-term data collected by Wildlife Rehabilitation Centres to assess threats to wildlife, guide awareness campaigns and support preventive actions. Additionally, such data can inform improvements in the design and operation of current and future facilities. Strengthening these centres is critical for effective wildlife recovery and biodiversity conservation in Brazil, one of the most biologically diverse countries in the world and increasingly affected by anthropogenic pressures
  • Item type: Publication ,
    Incomplete synapsis and chiasma localization: The chicken or the egg?
    (Karger Publishers, 2010-04-13) Viera Vicario, Alberto; Santos, Juan Luis; Parra Catalán, María Teresa; Calvente, Adela; Gómez Lencero, Rocío; Fuente Pita, Roberto de la; Suja Sánchez, José Ángel; Page Utrilla, Jesús; García de la Vega, Carlos; Rufas, Julio S.; Facultad de Ciencias; Departamento de Biología
    In the present study, and as a sincere tribute from the Cytogenetics teams from Madrid to Professor Máximo Drets on his 80th birthday, we have analyzed and compared 3 different grasshopper species with different synaptic patterns, a standard pattern, a second pattern with synapsis restricted to the proximal regions, and a third pattern with synapsis restricted to the distal regions. In the 3 species we have thoroughly analyzed the relationships among cohesin axis morphogenesis, formation of double strand breaks (DSBs) and recombination initiation. Our results demonstrate that in every case recombination initiation precedes synapsis, and that there is a direct relationship between the absence of meiotic recombination and the existence of particular unsynapsed chromosomal regions during prophase I. Based on our results we propose and discuss the mechanisms underlying the existence of incomplete synapsis and the localization of chiasma in wild species
  • Item type: Publication ,
    Replacing natural savannas with eucalyptus and soybeans changes the matrix use and reduces bat taxonomic and functional diversity in the Amazonian savannas
    (Elsevier, 2025-10-06) Xavier, Bruna S.; Mustin, Karen; Marques, Tiago M.; Ferreira, Marcelo M.; Hilário, Renato R.; Toledo, José J.; Castro, Isaí J.; Palmeirim, Jorge M.; Santos, Ana M.C; Vieira, Marcus V.; Mustin Carvalho, William Douglas; Departamento de Ecología; Facultad de Ciencias
    Amazonian savannas are a mosaic dominated by shrub or herbaceous vegetation (savannas) that surrounds other habitats, such as forest patches. For bats, the savanna functions as a permeable matrix, and its replacement by agricultural systems can alter the way bats use the matrix and therefore the movement of individuals between forest patches. Our aim was to understand the consequences for taxonomic and functional diversity of replacing natural savannas with eucalyptus plantations and soybean fields in phyllostomid and mormoopid bats. We used Generalised Linear Mixed Models to: 1) compare bat assemblages from forest patches and savannas in ten natural landscapes of the northeastern Brazilian Amazon with forest patches and agricultural systems in seven cultivated landscapes with soybean fields and seven with eucalyptus plantation; and 2) investigate how the agricultural system cover in the landscape, the structural complexity of the matrix and the local availability of fruits change bat assemblages. The replacement of natural savanna with eucalyptus plantations and soybean fields leads to changes in the bat assemblage both in the matrix itself and in forest patches surrounded by this modified matrix. We found that bats continue to use the landscape after the savanna matrix is replaced with eucalyptus plantations, but stop using the matrix when it becomes a soybean field. In forest patches, we found higher species richness but lower functional and taxonomic evenness in eucalyptus landscapes, and higher bat densities (refuge effect) due to a decrease in matrix permeability in soybean landscapes. Considering all landscapes, bats’ response to matrix change is explained by the matrix vegetation height, fruit availability and the agricultural system cover. The results show the importance of matrix management for conservation of species within forest fragment refuges in anthropized landscapes. We conclude that forest patches in anthropized landscapes should be conserved, but that savanna remnants must also be prioritised in order to maintain landscape heterogeneity and the movement of individuals between forest patches. Furthermore, arboreal or shrubby elements should be established in soybean fields to provide a more bat-friendly matrix. Finally, implementing laws targeted to maintaining natural habitats’ heterogeneity within each biome could improve landscape management
  • Item type: Publication ,
    Use of darvadstrocel (allogenic stem cell therapy) for Crohn’s fistulas in real clinical practice: The national project to implement mesenchymal stem cell for the treatment of perianal Crohn’s fistula (the PRIME study)
    (Wolters Kluwer, 2024-04-11) Herreros, María Dolores; Ramírez, José Manuel; Otero Piñeiro, Ana; Martí Gallostra, Marc; Badiola, Izaskun; Enríquez Navascués, José; Millán, Mónica; Barreiro, Erica M.; Portilla, Fernando de la; Suárez Alecha, Javier; García Olmo, Damián; National Project to Implement Mesenchymal Stem Cell for the Treatment of Perianal Crohn’s Fistula (the PRIME Study) Group; Departamento de Cirugía; Facultad de Medicina
    BACKGROUND: Perianal fistulas may affect 15% to 50% of patients with Crohn’s disease. Treatment is complex, requiring a multidisciplinary approach. Darvadstrocel (allogenic mesenchymal cells obtained from lipoaspirates) was approved in 2018 by the European and Spanish Agencies of Medicines and Medical Products as a treatment for fistulas in Crohn’s disease. Recent guidelines from the European Crohn’s and Colitis Organisation and Spanish Working Group on Crohn’s Disease and Ulcerative Colitis state that darvadstrocel is effective with a favorable safety profile and a strong level of evidence (n = 2). OBJECTIVE: Presenting real-world effectiveness data for darvadstrocel in a Spanish population. DESIGN: Observational retrospective cohort study with prospective data gathering. SETTINGS: The study was conducted at 14 institutions in Spain. PATIENTS: From November 2019 to April 2022, all patients (n = 73) treated with darvadstrocel in these institutions were included, fulfilling the following criteria: 1) complex fistula/s in a patient with Crohn’s disease; 2) failure of conventional and antitumor necrosis factor treatment; and 3) the absence of collections of >2 cm confirmed by pelvic MRI at the time of surgery. INTERVENTIONS: Darvadstrocel treatment. MAIN OUTCOME MEASURES: Clinical response (closure of 50% or more of external openings), complete clinical closure (100% of external openings), and radiological closure (no fluid collection >2 cm, edema, or inflammation) evaluated 6 months after treatment. RESULTS: Clinical response was observed in 63 patients (86.3%), complete clinical closure in 50 patients (68.5%), and radiological closure in 45 patients (69.2%). Combined clinical and radiological response was observed in 41 patients (63.1%). Not all clinically healed patients had radiological closure, and vice versa. No serious adverse events were reported. LIMITATIONS: Retrospective nature of the study. CONCLUSIONS: Study results were consistent with those reported in previous clinical trials, real-world efficacy findings from the INSPIRE study (assessing darvadstrocel effectiveness in Europe, Israel, Switzerland, United Kingdom, and Japan), and previously published literature. Darvadstrocel was effective and demonstrated a favorable safety profile when used in normal clinical practice for the treatment of fistulas in Crohn’s disease
  • Item type: Publication ,
    The multi-dimensional halo assembly bias can be preserved when enhancing halo properties with HALOSCOPE
    (EDP Sciences, 2025-05-08) Ramakrishnan, Sujatha; González Pérez, Violeta; Parimbelli, Gabriele; Yepes Alonso, Gustavo; Departamento de Física Teórica; Facultad de Ciencias
    Context. Over 90% of dark matter haloes in cosmological simulations have unresolved properties. This can hinder the dynamical range of simulations and result in systematic biases when modelling cosmological tracers. Current methods for enhancing unresolved haloes cannot preserve the multi-dimensional assembly bias found in simulations. Aims. We aim to more precisely determine unresolved structural and dynamical halo properties while preserving the correlations with environment and halo assembly bias found in simulations. Methods. We have developed HALOSCOPE, a machine learning technique that uses multi-variate conditional probability distribution functions. This method ensures that correlations among various halo properties, as well as their dependence on the local environment, are preserved. In this work, we trained HALOSCOPE with a high-resolution (HR) simulation and used it to better determine the properties (concentration, spin, and two shape parameters) of unresolved dark matter haloes in an eight times lower resolution simulation. Results. HALOSCOPE is able to recover the multi-dimensional halo assembly bias, that is, the correlations of different combinations of halo properties with the large-scale environment, measured in the HR simulation. This is achieved by including the linear halo-by-halo bias and tidal anisotropy in the set of input training parameters. HALOSCOPE, by design, also recovers the joint distribution of the halo properties. To study how resolution effects propagate into the clustering of model galaxies, we generated catalogues of central galaxies using two implementations of the assembly bias in a halo occupation distribution model. The clustering of central model galaxies is improved by a factor of three at 0.009
  • Item type: Publication ,
    Conflictos entre arte, ciencia y autoridad. El efecto Matilda en la cultura visual
    (Ediciones Complutense, 2022-12-22) Garrido Moreno, Elisa; Departamento de Historia y Teoría del Arte; Facultad de Filosofía y Letras
    Los estudios en comunicación de la ciencia han demostrado la importancia que la cultura científica tiene para la sociedad. Bajo una perspectiva de género, se ha demostrado que el llamado efecto Matilda ha generado una recepción masculinizada de la ciencia, un sesgo visiblemente presente en los medios de comunicación. Este trabajo propone analizar los orígenes de la visión masculinizada de la ciencia a través de las artes visuales. Objetivos y metodología. Vivimos en la era de las imágenes, pero, cuando tales imágenes han sido proyectadas abrumadoramente por actores masculinos, es difícil encontrar otros perfiles representados en posiciones de autoridad y desarrollo de conocimiento, contribuyendo a una imagen sesgada del mundo. Este trabajo se basa en un análisis de diversas obras de arte que legitiman el Efecto Matilda en espacios visuales para el conocimiento, como los museos, donde los grandes referentes de la ciencia siguen siendo, primordialmente masculinos. Resultados y discusión. Entendiendo la cultura científica como una de las cuestiones principales para la educación ciudadana y las artes visuales como uno de los medios más significativos para el aprendizaje significativo y el desarrollo de la capacidad crítica, los resultados subyacentes nos llevan a abogar por una futuro donde la diversidad de perfiles científicos e investigadores es un hecho, siendo necesario revisar el discurso de la representación visual de la ciencia hecha por mujeres y de lo que nuestra cultura ha representado, a lo largo de la historia del arte, como imagen de la autoridad científica
  • Item type: Publication ,
    Revealing Developmental Transitions in Perinatal andInfant Individuals Through Microanatomical Analysis
    (Wiley, 2025-07-14) Molina Moreno, María; Doe, Danielle M.; Candelas González, Nieves; García Martínez, Daniel; González Martín, Armando; Cambra Moo, Óscar; Agencia Estatal de Investigación; Comunidad de Madrid; Departamento de Biología; Facultad de Ciencias
    Objectives: Identifying signs of birth in perinatal human remains of past populations is challenging due to the lack of direct markers of this event on bones. This research aims to identify distinct events in humeral cross-sections microanatomy related to perinatal development and to integrate the findings into infant mortality trends. Material and Methods: The sample consists of infants (N = 106) ranging from prenatal to 1.5 years, with microanatomical analysis of nine selected individuals. Age-at- death estimation and microanatomical characterization were conducted, combined with quantitative analysis of microanatomical features. Results: Biological age-at- death presents high variability and overlap across prenatal to postnatal stages. Microanatomical analysis reveals a higher percentage of mineralized areas (60%–80%) within the total cross-sectional area in the youngest individuals up to the first neonatal month. Conclusions: Based on the integration of microanatomical analysis in an extensive infant sample, this study highlights the evidence of developmental transitions from prenatal to neonatal stages. These findings suggest that, unlike biological age estimation methods, the full-term period can be identified microanatomically in bone. This provides a valuable approach for analyzing fragmented skeletal remains, secondary deposits, and other funerary or osteological contexts, opening new pathways to understand gestational development and postnatal survival in past populations
  • Item type: Publication ,
    A. K. Wollstonecraft: una ilustradora botánica del siglo XIX en la isla de Cuba. Principales datos biográficos y una aproximación a su obra Specimens of the plants and fruits of the Island of Cuba (1826)
    (CSIC, 2023-05-24) Garrido Moreno, Elisa; Departamento de Historia y Teoría del Arte; Facultad de Filosofía y Letras
    Nancy Anne Kingsbury Wollstonecraft nació en octubre de 1781. Los primeros datos que tenemos sobre ella la sitúan en Estados Unidos, desde donde viajaría a Matanzas (Cuba), residiendo varios años allí y trabajando en una gran obra de botánica ilustrada, hasta su muerte, el 16 de mayo de 1828. La obra de Nancy Anne Kingsbury Wollstonecraft –a partir de ahora, A. K. Wollstonecraft– com-prende observaciones sobre más de cien especies vegetales de la Isla de Cuba, datos sobre la etimología de su nomenclatura, usos y aplicaciones de las plantas, así como datos sobre los hechos históricos que la rodean y sus propias reflexiones personales. Esto convierte a esta obra en un manuscrito extraordinario que transita entre la ciencia, el arte y el relato de viajes. En este artículo se presentan las principales referencias de los datos biográficos conocidos hasta el momento y un análisis introductorio a su obra botánica ilustrada
  • Item type: Publication ,
    El cuaderno de Blanca Catalán de Ocón. Memoria de una naturalista entre la botánica, las artes y la poesía
    (Universidad de Las Palmas de Gran Canaria, 2025-01-20) Garrido Moreno, Elisa; Departamento de Historia y Teoría del Arte; Facultad de Filosofía y Letras
    La botánica Blanca Catalán de Ocón y Gayolá (1860-1904) vivió su juventud rodeada de la belleza de la naturaleza, el saber científico y el gusto la poesía que se respiraba en cada rincón de su hogar; un inmenso valle en el corazón de la Sierra de Albarracín. Elaboró un detallado herbario con más de ochenta especies, algunas desconocidas para la ciencia. Sin embargo, la naturaleza fue para ella mucho más que un elemento a analizar científicamente. Se convirtió en fuente de inspiración, manifestada en poemas y composiciones florales. En este trabajo examinamos su herbario y archivo personal, reflexionando sobre las prácticas que vincularon las artes y la botánica como estrategia para crear espacios alternativos de discusión científica
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    Trementinaires. Gender, collecting, and subsistence in the Pyrenees
    (Gewina, 2022-11-11) Garrido Moreno, Elisa; Departamento de Historia y Teoría del Arte; Facultad de Filosofía y Letras
    This paper presents a case study on the links between natural history, female agency and self-care strategies in relation to the legacy of a female collective known as the trementinaires. The trementinaires were a group of female workers who traveled around the High Pyrenees, collecting plants and selling herbal medicines they made themselves. Their name derived from the word trementina (turpentine) since they were particularly recognized for their work as makers of turpentine. They were popularly known from the nineteenth century onward for their trustworthy knowledge of local medicinal herbs and their properties, as well as where to find them and when to collect them. Their story is linked to the valley in which they lived and the different gender roles developed through a social situation in which women led the economic support of the family. To subsist, these women developed their knowledge of herbs, local plants and products, improving the tools through which they gained a specialized collection of conservation techniques and recipes that they could use and transmit from grandmothers to mothers and daughters. This paper reflects on their relevance today and demonstrates how they challenged the traditional family roles based on a gendered knowledge of the environment and its resources
  • Item type: Publication ,
    Madres deshumanizadas. La invisibilidad del oficio de nodriza en Cuba
    (CSIC, 2023-12-30) Garrido Moreno, Elisa; Gobierno de España; Departamento de Historia y Teoría del Arte; Facultad de Filosofía y Letras
    El artículo analiza la imagen de las nodrizas en Cuba, a partir del imaginario que nos ha llegado de ellas con la nodriza cubana como tema principal. Se analizan, por una parte, las escasas imágenes existentes de amas de leche cubanas en lienzo y fotografía de finales del siglo XIX y, por otra, unas tarjetas postales de principios del siglo XX. A través de este análisis se muestra el proceso de cancelación y deshumanización que sufrieron las nodrizas, habitualmente afrodescendientes, en las sociedades esclavistas atlánticas como la cubana
  • Item type: Publication ,
    Unveiling the Dual Nature of the Smallest Aqueous Ferrocene Complex
    (John Wiley & Sons, 2025-03-07) Blanco, Susana; Verde, Andrés; Lopez, Juan Carlos; Yáñez Montero, Manuel; Montero Campillo, M. Merced; Alkorta, Ibon; Gobierno de España; Junta de Castilla y León; Departamento de Química; Facultad de Ciencias
    The structure of the ferrocene-water ((Cp)2Fe:H2O) complex has been characterized by combining state of the art rotational spectroscopy and computational chemistry. Two structures have been retrieved experimentally where water interacts with two distinguished binding sites, the exo Cp π cloud and the planetary-like planar orbit around iron. The spectra of both conformers exhibit significant averaging effects due to the nearly free rotational dynamics of water. This is in good agreement with the exploration of the potential energy surface of (Cp)2Fe:H2O. For water interacting with the exo Cp π cloud, we found three axial conformers giving rise to twenty minima with small internal rotation barriers. Theoretical calculations reveal two minima for the observed equatorial complex. Water interacts with ferrocene quite strongly, exhibiting binding energies above −11 kJ/mol in all binding sites and contributing to small deformations in the structure of bare ferrocene
  • Item type: Publication ,
    Sexenios y acreditaciones de profesorado universitario: control judicial de la discrecionalidad técnica
    (Editorial Bercal, 2024-09-02) Quicios Molina, Susana; Facultad de Derecho; Departamento de Derecho Privado, Social y Económico
    La Sentencia de 23 de mayo de 2024, de la Sala de lo Contencioso-Administrativo del Tribunal Supremo, no considera necesario retrotraer las actuaciones para que sea la Comisión Nacional de Evaluación de Actividad Investigadora (CNEAI), como administración evaluadora y con base en el juicio técnico del comité de expertos correspondiente, la que decida la concesión o no del sexenio de transferencia solicitado por el recurrente. Ese juicio técnico, como consecuencia de la anulación por insuficiente motivación del acto administrativo de denegación del sexenio, puede llevarlo a cabo el tribunal de instancia con apoyo en la prueba pericial practicada (concretamente, un informe emitido por un profesor de la misma universidad del demandante). Esta doctrina sobre control judicial de la discrecionalidad técnica de la Administración se apoya en la recogida en la Sentencia de la misma Sala de 25 de abril de 2024 (sobre la declaración de “no apto” de un aspirante a policía en la prueba de entrevista personal), pero, por lo que respecta a la evaluación del profesorado universitario como supuesto específico de ejercicio de dicha discrecionalidad, se aparta de jurisprudencia previa de la misma Sala