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Thyroid Hormone Transporters MCT8 and OATP1C1 Are Expressed in Projection Neurons and Interneurons of Basal Ganglia and Motor Thalamus in the Adult Human and Macaque Brains
(MDPI, 2023-06-01) Wang, Ting; Wang, Yu; Montero-Pedrazuela, Ana; Prensa Sepúlveda, Lucía; Guadaño Ferraz, Ana; Rausell Tamayo, Estrella; Gobierno de España; Departamento de Anatomía, Histología y Neurociencia; Facultad de Medicina
Monocarboxylate transporter 8 (MCT8) and organic anion-transporting polypeptide 1C1 (OATP1C1) are thyroid hormone (TH) transmembrane transporters relevant for the availability of TH in neural cells, crucial for their proper development and function. Mutations in MCT8 or OATP1C1 result in severe disorders with dramatic movement disability related to alterations in basal ganglia motor circuits. Mapping the expression of MCT8/OATP1C1 in those circuits is necessary to explain their involvement in motor control. We studied the distribution of both transporters in the neuronal subpopulations that configure the direct and indirect basal ganglia motor circuits using immunohistochemistry and double/multiple labeling immunofluorescence for TH transporters and neuronal biomarkers. We found their expression in the medium-sized spiny neurons of the striatum (the receptor neurons of the corticostriatal pathway) and in various types of its local microcircuitry interneurons, including the cholinergic. We also demonstrate the presence of both transporters in projection neurons of intrinsic and output nuclei of the basal ganglia, motor thalamus and nucleus basalis of Meynert, suggesting an important role of MCT8/OATP1C1 for modulating the motor system. Our findings suggest that a lack of function of these transporters in the basal ganglia circuits would significantly impact motor system modulation, leading to clinically severe movement impairment
Thyroid Hormone Transporters MCT8 and OATP1C1 Are Expressed in Pyramidal Neurons and Interneurons in the Adult Motor Cortex of Human and Macaque Brain
(MDPI, 2023-02-06) Wang, Yu; Wang, Ting; Montero Pedrazuela, Ana; Guadaño Ferraz, Ana; Rausell Tamayo, Estrella; Gobierno de España; Departamento de Anatomía, Histología y Neurociencia; Facultad de Medicina
Monocarboxylate transporter 8 (MCT8) and organic anion transporter polypeptide 1C1 (OATP1C1) are thyroid hormone (TH) transmembrane transporters that play an important role in the availability of TH for neural cells, allowing their proper development and function. It is important to define which cortical cellular subpopulations express those transporters to explain why MCT8 and OATP1C1 deficiency in humans leads to dramatic alterations in the motor system. By means of immunohistochemistry and double/multiple labeling immunofluorescence in adult human and monkey motor cortices, we demonstrate the presence of both transporters in long-projection pyramidal neurons and in several types of short-projection GABAergic interneurons in both species, suggesting a critical position of these transporters for modulating the efferent motor system. MCT8 is present at the neurovascular unit, but OATP1C1 is only present in some of the large vessels. Both transporters are expressed in astrocytes. OATP1C1 was unexpectedly found, only in the human motor cortex, inside the Corpora amylacea complexes, aggregates linked to substance evacuation towards the subpial system. On the basis of our findings, we propose an etiopathogenic model that emphasizes these transporters’ role in controlling excitatory/inhibitory motor cortex circuits in order to understand some of the severe motor disturbances observed in TH transporter deficiency syndromes
Madame d'Aulnoy: Versalles visita Madrid
(Ediciones La Librería, 2023) Pérez-Castilla Álvarez, Javier; Departamento de Filologías y su Didáctica; Facultad de Formación de Profesorado y Educación
La dama francesa escribió un famoso libro sobre su estancia en la corte de los Austrias a finales del siglo XVII. En ese texto proyecta, junto a interesantes apreciaciones sobre la actividad dramática, la gastronomía, la tauromaquia y, en general, las costumbres madrileñas, los prejuicios de una noble extranjera educada en los usos y en la etiqueta versallesca. El éxito de esta distorsionada visión fue extraordinario y condicionaría a los escritores europeos que en siglos posteriores visitaron nuestra ciudad
Engineering 3D Pd/AC catalysts for the continuous production of hydrogen from formic acid
(Elsevier, 2025-09-01) Martin, Celia; Diaz-Herrezuelo, Irene; Navarro, Marina; Sanz Abengozar, Isabel; Casas de Pedro, José Antonio; Belmonte, Manuel; Quintanilla Gómez, María Asunción; Gobierno de España; Departamento de Ingeniería Química; Facultad de Ciencias
Formic acid is a liquid organic hydrogen carrier for the safe hydrogen storage and transport. This study presents the fabrication of 3D-printed activated carbon (AC) monoliths by robocasting and their use as supports for Pd- based catalysts in the continuous hydrogen production (25–55 ◦C, 0.5–1 M FA, τ =20–540 gCAT h L 1). The aim is to identify the optimal internal architecture for process scale-up. While monolith geometry does not alter Pd nanoparticle properties (size ~ 2.2 nm, dispersion 20–28%, Pd2+/Pd0 =1), it significantly affects flow behaviour and structural robustness. The optimal design, incorporating a central axial channel, achieves initial TOFs up to 5087 h 1 at 55 ◦C. After over 100 h of operation, only a 23% activity loss is observed. Kinetic analysis reveals a second-order rate law in FA and 36 kJ mol 1 activation energy. These results demonstrate the potential of engineered 3D Pd/AC monoliths for efficient and scalable hydrogen production
Observation of charge density wave excitonic order parameter in topological insulator monolayer WTe2
(ACS, 2025-09-04) Watson, Liam; Ripoll Sau, Joan; Tong, Zhengjue; Kumar, Amit; Que, Yande; Chan, Yang-Hao; Lin, Hsin; Mukherjee, Shantanu; Garnica Alonso, Manuela; Edmonds, MarkT.; Papaj, Michal; López Vázquez de Parga, Amadeo; Weber, Bent; Di Bernardo, Iolanda; Fuhrer, Michael S.; Gobierno de España; Departamento de Física de la Materia Condensada; Facultad de Ciencias
Strong electron−hole interactions in a semimetal or narrow-gap semiconductor may drive a ground state of condensed excitons. Monolayer WTe2 has been proposed as a host material for such an exciton condensate, but the order parameter the key signature of a macroscopic quantum-coherent condensate has not been observed. Here, we use Fourier-transform scanning tunneling spectroscopy (FT-STS) to study quasiparticle interference (QPI) and periodic modulations of the local density of states (LDOS) in monolayer WTe2. In WTe2 on graphene, in which the carrier density can be varied via back-gating, FT-STS shows QPI features in the two-dimensional (2D) bulk bands, confirming the interacting nature of the bandgap in neutral WTe2 and the semimetallic nature of highly n- and p-doped WTe2. We observe additional nondispersive spatial modulations in the LDOS imprinted on the topological edge mode of neutral WTe2 on metallic substrates (graphene and graphite), which we interpret as the interaction of the topological edge mode with the expected charge density wave order parameter of the excitonic condensate in WTe2 at low interaction strength due to screening by the metallic substrates
The Behavioral Education in Social Media (BE‑Social) Program for Postgraduate Academic Achievement: A Randomized Controlled Trial
(Springer Nature, 2024-03-28) Tarifa Rodríguez, Aida; Virues-Ortega, Javier; Calero Elvira, Ana; Gobierno de España; Análisis de la conducta verbal en contextos clínicos con metodología observacional. (SOC PS-031); Departamento de Psicología Biológica y de la Salud; Facultad de Psicología
Few randomized controlled trials have evaluated social media study groups as educational aids in the context of online and blended teaching programs. We present the Behavioral Education in Social Media (BE-Social) intervention package, which integrates key evidence-informed behavioral intervention strategies delivered through a closed social media study group. BE-Social combines instructor-mediated cooperative learning and self-management training via multimedia posts and video modeling. Forty-six students were randomly assigned to a default online program (control) group or default online program plus BE-Social (intervention) group. Intervention outcomes included academic performance and social media engagement (reactions, comments). A mixed-effect ANOVA showed that individuals in the BE-Social group attained higher academic performance, F (1, 46) = 18.37, p < .001, η2 = .34). On average, the intervention produced a 20-point increase in academic performance over a 100-point scale and significant increases in social media engagement. A parallel single-subject analysis revealed that intervention gains were not always consistent across participants. Findings are consistent with the view that social media platforms provide a prosthetic social milieu that can enrich traditional education by maximizing social rewards through increased interaction opportunities and timely positive feedback. We propose the digital environment reward optimization hypothesis to denote these processes
Delayed photoisomerisation of the trans-PSB3 retinal toy model using on-the-fly quantum dynamics
(RSC, 2025-08-01) Mallo, María; Gómez-Carrasco, Susana; Gómez, Sandra; Gobierno de España; Departamento de Química; Facultad de Ciencias
We explore the trans–cis photoisomerisation process in a representative retinal protonated Schiff base known as trans-PSB3, employing the quantum dynamics method direct dynamics variational multiconfigurational Gaussian -DD-vMCG- in full dimensionality, i.e., 36 degrees of freedom on potential energy surfaces computed on-the-fly using the SA(2)-CAS(6,6)SCF electronic structure method with the 6-31G basis set. Although the toy molecule has been extensively studied using trajectory methods such as Tully surface hopping and ab initio multiple spawning, our application of the on-the-fly quantum dynamics method DD-vMCG reveals a previously unreported trans–cis isomerisation pathway throughthe S1 electronic state minimum that occurs hundreds of femtoseconds more slowly, despite using the same electronic structure method. This slower timescale and alternative deactivation route can be explained in terms of the accesibility to the conical intersections connecting the ground and the excited state
El aristotelismo después de Sila. ¿La (des)legitimación de un corpus?
(Fabrizio Serra, 2025) Zamora Calvo, José María; Departamento de Filosofía; Facultad de Filosofía y Letras
A partir de un análisis de fuentes procedentes fundamentalmente de Estrabón, Plutarco y Posidonio, este artículo se propone abordar la transmisión de los textos de Aristóteles después de 84 a.C., fecha en la que Sila los traslada de Atenas a Roma. Los manuscritos de Aristóteles y de Teofrasto permanecen como propiedad particular de la familia de Neleo en Escepsis hasta la segunda mitad del II a.C., momento en que afloran de nuevo. Apelicón consigue obtener los originales y, una vez de regreso a Atenas, se produce su diseminación. En Roma Andronico adquiere y transmite los textos, ordenados y preparados por Tiranión a partir de los originales de la biblioteca de Apelicón, pero en su trabajo crítico de edición y catalogación incorpora elementos de la tradición alejandrina, que permiten la «legitimación» del corpus. Cincuenta años separan el floruit de Apelicón del de Andronico. Cómo se estableció en este período el corpus aristotélico es, pues, el tema principal discutido en este artículo
Narrativas de la guerra en la iconografía medieval hispana. La iluminación del primer manuscrito del Fortalitium fidei
(Ediciones Universidad de Salamanca, 2022-05-12) Palacios Ontalva, José Santiago; Departamento de Historia Antigua, Medieval, Paleografía y Diplomática; Facultad de Filosofía y Letras
El ms. 154 de El Burgo de Osma, el primero conocido del Fortalitium fidei de Alonso de Espina, contiene una serie de representaciones relacionadas con distintas guerras libradas entre cristianos y musulmanes a lo largo de la Historia, en su mayoría desconocidas hasta ahora. Este artículo propone el análisis iconográfico de esa iluminación, y su encuadre en el estudio de la iconografía bélica desarrollada al final de la Edad Media en la península ibérica. El interés preferente de este trabajo se centra en las escenas de batalla, así como en la complementaria relación entre textos e imágenes que originan las narraciones plásticas del conflicto, y que, en su caso, nos ayudan a su identificación y contextualización historiográfica
Giacomo Casanova, un libertino en Madrid
(Ediciones La Librería, 2023-09-28) Pérez-Castilla Álvarez, Javier; Departamento de Filologías y su Didáctica; Facultad de Formación de Profesorado y Educación
El autor italiano visitó Madrid durante el reinado de Carlos III. Las páginas de sus Memorias dedicadas a la capital de España ofrecen un valioso testimonio acerca de los espectáculos, las costumbres, los pintores, la monarquía y, en general, la sociedad madrileña del siglo xviii. Asimismo, esa visión refleja perfectamente los ideales y los prejuicios de un viajero ilustrado
Assessment design decisions in practice: Profile identification in approaches to assessment design
(Taylor & Francis, 2022-06) Fernández Ruiz, Javier; Panadero, Ernesto; García Pérez, Daniel; Pinedo, Leire; Agencia Estatal de Investigación; Departamento Interfacultativo: Facultad de Formación de Profesorado y Educación y Facultad de Psicología; Departamento de Psicología Evolutiva y de la Educación; Facultad de Psicología
This study aims to identify different profiles of higher education teachers based on the way they design their assessment methods. It also explores differential characteristics in each profile and differences in the assessment methods preferred by the teachers and those implemented in their subjects. Seventeen teachers from four universities participated carrying out a think-aloud simulation task: designing the assessment methods for a set of learning outcomes. Teachers’ testimony during the task was transcribed and categorized using content analysis and an open-coding procedure. Three different patterns were identified: (a) focus on the feasibility of the assessment tasks, (b) on the alignment with the learning outcomes, or (c) alignment with teaching methods. Most of the participants focused only in one of the three elements. Teachers also designed different assessment methods in the simulation task in comparison with the ones they use in their subjects, despite the guidelines of assessing the same learning outcomes. A lack of resources is claimed as the reason of these differences. Implications for future research are discussed
AI4Food, a feasibility study for the implementation of automated devices in the nutritional advice and follow up within a weight loss intervention
(Elsevier, 2025-05) Lacruz-Pleguezuelos, Blanca; Bazán, Guadalupe X.; Romero-Tapiador, Sergio; Freixer, Gala; Tolosana Moranchel, Rubén; Daza García, Roberto; Fernández-Díaz, Cristina M.; Molina, Susana; Crespo, Maria del Carmen; Laguna, Teresa; Marcos-Zambrano, Laura Judith; Aguilar-Aguilar, Elena; Fernandez-Cabezas, Jorge; Cruz-Gil, Silvia; Fernandez, Lara P.; Vera Rodríguez, Rubén; Fiérrez Aguilar, Julián; Ramírez de Molina, Ana; Ortega García, Javier; Morales Moreno, Aythami; Carrillo de Santa Pau, Enrique; Espinosa-Salinas, Isabel; Comunidad de Madrid; Gobierno de España; Departamento de Tecnología Electrónica y de las Comunicaciones; Departamento de Ingeniería Informática; Escuela Politécnica Superior
Background & aims The widespread prevalence of NCDs calls for an improvement in their prevention and treatment. Wearable technologies can be an important asset in the development of precision nutrition strategies, for both health professionals and patients. However, their clinical use is hindered by a lack of validation against current methodologies or appropriate tools to deliver nutritional strategies based on their data. Our study includes manual and automatic data capture methods within a weight loss intervention with the aim to create an essential asset for the implementation, validation, and benchmarking of AI-based tools in nutritional clinical practice. Methods This is a feasibility prospective and crossover controlled trial for weight loss in overweight and obese participants, randomized into two groups: Group 1 used manual data collection methods based on validated questionnaires for the first two weeks; while Group 2 started with automatic data collection methods consisting of wearable sensors. After two weeks, the two groups switched data collection methods. Lifestyle data, anthropometric measurements and biological samples were collected from all participants. Results A total of 93 participants completed the nutritional intervention designed for weight loss, achieving a mean reduction of 2 kg (V1: 84.99 SD ± 13.69, V3: 82.72 SD ± 13.32, p < 0.001). Significant reductions were observed in body mass index, visceral fat, waist circumference, total cholesterol, and HbA1c levels. The use of electronic devices proved satisfactory among the participants (System Usability Scale score 78.27 ± 12.86). We also report the presence of distinct patient groups based on continuous glucose measurements. Conclusion This study has yielded a large amount of data and has showcased how automatic data collection devices can be employed to gather data in the context of a nutritional intervention. This will enable the implementation of AI-based tools in nutritional clinical practice
Cocoa shell extract restores redox balance in developmental hypertension in male rats: Roles of Nrf2, SOD2 and p-eNOS
(MDPI, 2025-09-23) Ruvira Hernando, Santiago; Rodríguez Rodríguez, Pilar; Iampanichakul, Metee; Cuquerella, Lucía G.; Ramiro Cortijo, Davil; Arribas Rodríguez, Silvia Magdalena; Gobierno de España; Agencia Estatal de Investigación; Alimentos, Estrés Oxidativo y Salud Cardiovascular; Departamento de Fisiología; Facultad de Medicina
Background and objectives: Hypertension is a worldwide burden, for which fetal malnutrition is a risk factor. Another societal challenge is environmental waste. Our research focusses on cocoa shell extract (CSE), a cocoa by-product with antioxidant bioactive components. Male rats exposed to fetal malnutrition develop hypertension and endothelial dysfunction, which are improved by CSE supplementation. We hypothesized that effects of CSE are related to an antioxidant action. Methods: Adult male and female offspring of dams exposed to 50% food restriction during gestation (MUN) and controls were supplemented for 3 weeks with CSE (250 mg/kg/day) or a vehicle. We assessed plasma SOD activity, GSH and carbonyls (via spectrophotometry) and aortic expression of enzymes related to ROS degradation or production (via Western blotting). Results: MUN males showed lower Nrf2 expression and increased carbonyls, SOD activity and mitochondrial SOD2 expression, without alterations in GSH or the related enzyme CGLM. No changes in xanthine oxidase or NADPH subunits (p22phox and p47phox) were detected, suggesting a different origin of superoxide anion. Phosphorylated-eNOS/eNOS and 3-nitrotyrosine expression were increased without changes in plasma nitrates. MUN females only showed plasma SOD and aortic 3-nitrotyrosine elevation. CSE supplementation reduced SOD2 and p-eNOS/eNOS expression and SOD activity and increased Nrf2 expression. Conclusions: MUN arteries exhibit oxidative damage, with a higher impact on males. SOD2 and p-eNOS/e-NOS overexpression may be a counteracting mechanism that compensates for superoxide anion overproduction, likely involving mitochondria. The reversal of these alterations by CSE supplementation is probably related to a reduction in vascular superoxide anion through a direct scavenging action of its bioactive components. A longer supplementation period may be needed to increase endogenous antioxidants through Nrf2 and to reduce oxidative–nitrosative damage
Assessment from a disciplinary approach: design and implementation in three undergraduate programmes
(Taylor & Francis, 2021) Fernández Ruiz, Javier; Panadero, Ernesto; García Pérez, Daniel; Agencia Estatal de Investigación; Departamento Interfacultativo: Facultad de Formación de Profesorado y Educación y Facultad de Psicología; Departamento de Psicología Evolutiva y de la Educación; Facultad de Psicología
The role of the academic discipline is a major factor in the assessment design and implementation in higher education. Unfortunately, a clear understanding of how teachers from different disciplines approach assessment is still missing; this information can lead to teacher training programmes that are better designed and more focussed. The present study compared assessment design and implementation in three programmes (sport science, mathematics, and medicine) each representing a discipline from 4 Spanish universities. Using a mixed-methods approach, data from syllabi (N = 385) and semi-structured interviews with teachers (N = 19) were analysed. The results showed different approaches to assessment design and implementation in each programme in two main axes: summative or formative purposes of assessment, and content-based or authentic assessment. Implications for further research are discussed
Vibrationally Resolved Photoionization Delays in the Water Molecule
(American Physical Society, 2025-11-26) Pranjal, Prateek; González Vázquez, Jesús; Bello, Roger Y.; Martín, Fernando; Martín García, Fernando; Agencia Estatal de Investigación; Comunidad de Madrid; Departamento de Química Física Aplicada; Departamento de Química; Facultad de Ciencias
We have implemented a theoretical approach to provide time- and vibrationally resolved photoelectron spectra and ionization time delays of polyatomic molecules as those expected from current high energy resolution reconstruction of attosecond beatings by interference of two-photon transitions setups. Its application to the H2⁡O molecule reveals that two-photon ionization delays extracted from the calculated photoelectron spectra do not vary monotonically with photon energy and can increase or decrease along the vibrational progressions. The difference between one- and two-photon ionization delays is substantially larger when the molecular cation is left in the symmetric stretching mode (up to 35 as, i.e., comparable to the actual ionization delays) rather than in the bending mode, thus showing a strong vibrational selectivity in the laser-photoelectron interaction. Hence, the variation of calculated two-photon delays with the final vibrational state does not simply reflect the energy dependence of the Coulomb phases, as usually assumed in a structureless electronic continuum, but also the changes in the molecular geometry associated with the different vibrational modes. As vibrational excitation accompanying the emission of a photoelectron is the rule rather than the exception in polyatomic molecules, the present Letter shows the importance of considering nuclear motion for a correct interpretation of ionization time delays.
La urticaria como dermatosis reumática en los aforismos de Olavide
(Academia Española de Dermatología y Venereología (AEDV), 2025-11-17) Díaz Díaz, Rosa María; Martín Hervás, Carmen; Departamento de Medicina; Facultad de Medicina
Female terminalia morphology and cladistic relations amongTok-Tok beetles (Tenebrionidae: Sepidiini)
(Wiley, 2022-07-04) Kamiński, Marcin J.; Gearner, Olivia M.; Raś, Marcin; Hunsinger, Elliot T.; Smith, Amelia L.; Mas-Peinado, Paloma; Girón, Jennifer C.; Bilska, Aleksandra G.; Strümpher, Werner P.; Wirth, Christopher C.; Kanda, Kojun; Swichtenberg, Kali; Iwan, Dariusz; Smith, Aaron D.; Departamento de Biología; Facultad de Ciencias
Tok-tokkies are one of the most iconic lineages within Tenebrionidae. In addition to containing some of the largest darkling beetles, this tribe is recognized for its remarkable form of sexual communication known as substrate tapping. Nevertheless, the phylogenetic relationships within the group remain poorly understood. This study investigates the usefulness of female terminalia morphology for delimiting Sepidiini and reconstructing relationships among it. Data on the structure of the ovipositors, genital tubes and spicula ventrali have been generated for >200 species representing 28 Pimeliinae tribes. This dataset was used in a comparative analysis at the subfamilial level, which resulted in recognition of several unique features of tok-tokkie terminalia. Additionally, new features linking phenotypically challenging tribes also were recovered (Cryptochilini + Idisiini + Pimeliini). Secondly, 23 characters linked to the structure of female terminalia were defined for tok-tok beetles. Cladistic analysis demonstrates the nonmonophyletic nature of most of the recognized subtribes. The morphological dataset was analysed separately and in combination with available molecular data (CAD, Wg, cox1, cox2, 28S). All obtained topologies were largely congruent, supporting the following changes: Palpomodina Kamiński & Gearner subtr.n. is erected to accommodate the genera Namibomodes and Palpomodes; Argenticrinis and Bombocnodulus are transferred from Hypomelina to Molurina; 153 species and subspecies previously classified within Psammodes are distributed over three separate genera (Mariazofia Kamiński nom.n., Piesomera stat.r., Psammodes sens.n.). Psammodes sklodowskae Kamiński & Gearner sp.n. is described. Preliminary investigation of the ovipositor of Mariazofia basuto (Koch) comb.n. was carried out with the application of microcomputed tomography, illuminating the muscular system as a reliable reference point for recognizing homologous elements in highly modified ovipositors
Approach to nursing diagnoses of people with myalgic encephalomyelitis / chronic fatigue syndrome: a qualitative meta-synthesis
(Taylor & Francis, 2025-07-01) Oter Quintana, Cristina; Esteban Hernández, Jesús; Cuéllar Pompa, Leticia; Gil Carballo, Candelas; Brito Brito, Pedro Ruymán; Martín García, Ángel; Alcolea Cosín, María Teresa; Martínez Marcos, María Mercedes; González Gil, María Teresa; Alameda Cuesta, Almudena; Departamento de Enfermería; Facultad de Medicina; Biblioteca Universitaria
Objective To identify human responses (diagnostic foci) that shape the experience of living with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and how they manifest throughout the course of the illness. Methods A qualitative meta-synthesis was conducted. Original studies exploring the experience of living with ME/CFS in adults with a confirmed diagnosis, published in English or Spanish between 1994 and June 2024, were included. The literature search was carried out in Medline/Medline In-Process, Embase, CINAHL, PsycINFO, SCI-EXPANDED, SSCI, SciELO, Lilacs, and Cuiden. Data analysis was based on the human responses (diagnostic foci) from the NANDA-I Nursing Diagnoses Classification, 2021–2023, with findings structured according to Fennell’s Four-Phase Model. Results A total of 42 articles were selected. Twenty human responses (diagnostic foci) and three classes of the NANDA-I Nursing Diagnoses Classification were identified, interwoven across the different phases of the model. Some responses were present throughout all phases, while others, such as Energy Balance and Health Self-Management, became particularly relevant from Phase 2 onwards. Phases 3 and 4 were characterised by losses and processes of subjective reconstruction, with diagnostic foci such as Sorrow, Spiritual Distress, and Personal Identity being predominant. Conclusions The identified human responses (diagnostic foci) highlight how the contested and chronic nature of ME/CFS profoundly shapes the lived experience of those affected. The model derived from this review provides a structured framework for targeted nursing interventions, aligned with the phase each individual is experiencing
Secondary education students’ self-assessment: the effects offeedback, subject matter, year level, and gender
(Taylor and Francis, 2020-10-30) Panadero, Ernesto; Fernández Ruiz, Javier; Sánchez Iglesias, Iván; Gobierno de España; Departamento de Psicología Evolutiva y de la Educación; Facultad de Psicología
The effects of relevant factors related to self-assessment have not been systematically investigated. We explored four factors and their effects on self-assessment and self-efficacy: (1) feedback (with vs without), (2) subject matter (Spanish vs mathematics), (3) year level (K7 vs K10 vs K11), and (4) gender. The participants included 64 secondary education students who self-assessed during a set of Spanish and mathematics activities while being video-recorded. Data came from think-aloud protocols, direct observations, and self-reported instruments. The use of self-assessment strategies and criteria was more frequent and advanced without feedback and in females. There were differences in the self-assessment of Spanish and mathematics. As for year level, results showed more similarities than expected, though the use of advanced strategies and criteria varied across levels. Additionally, none of the factors had significant effects on self-efficacy. This study opens a new avenue for self-assessment research, unveiling the black box of self-assessment
Plant functional traits shape the provision of ecosystem services to Indigenous communities in western Amazonia
(Wiley-Blackwell Publishing Ltd, 2025-10-30) Aledo, Julia G. de; Steege, Hans ter; Cayuela, Luis; Matas-Granados, Laura; Ben Saadi, Celina; Salinas, Norma; La Torre-Cuadros, María de los Ángeles; Báez, Selene; Bañares-de-Dios, Guillermo; Cayola, Leslie; Fadrique, Belén; Farfán-Rios, William; Fuentes, Alfredo; Homeier, Jürgen; Jadán, Oswaldo; Tello, J. Sebastián; Macía Barco, Manuel Juan; Agencia Estatal de Investigación; Departamento de Ecología; Facultad de Ciencias; Departamento de Biología
1. Context. Exploring how Indigenous People interact with plants through their functional traits allows us to understand the ecological bases of plant selection. Functional traits can help explain why certain plants are consistently chosen for specific purposes across diverse cultural contexts. However, these relationships are complex and remain insufficiently explored. Here, we ask (1) which functional traits are most important in shaping different uses? and (2) do similarities in trait– use associations across Indigenous communities reflect patterns of knowledge convergence? 2. Methods. We conducted fieldwork across nine different Indigenous communities spanning a 1800 km distance in western Amazonia. In total, we sampled 115 0.1-ha plots, recording the abundance of 1856 woody plant species. For these species, we collected data on 13 different functional traits, primarily measured in the field, with additional values sourced from TRY and other databases, and conducted in situ ethnobotanical interviews with 25 Indigenous male participants, focusing on 14 distinct use categories. We analysed (1) trait–use relationships using generalized linear models and (2) the similarity in trait selection for each use across communities using generalized linear mixed models. 3. Results. Plants used for medicine or food were associated with multiple traits, including reproductive traits, exudates and life form. In contrast, culturally specific uses such as rituals, cosmetics or recreational were linked to more specific traits, particularly wood density and lianas. Across communities, we observed widespread convergence in trait–use associations, suggesting shared patterns of plant use despite cultural differences. However, 24% of the trait–use combinations showed divergence, indicating local adaptation or cultural specificity. 4. Synthesis and applications. Plant selection by Indigenous communities is not random; rather, it is guided by functional traits that consistently support human well-being. We named this pattern ‘functional selection convergence’, highlighting how ecological function and traditional knowledge interact across distinct cultural contexts. This convergence shows the importance of functional ecology explaining traditional plant selection. Our findings are a call for a trait-based ethnobotanical approach to document and better preserve the ecosystem services essential to Indigenous livelihoods. Nevertheless, we emphasize the need for future research to involve broader and more diverse ethnobotanical participation.

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