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Venous thrombosis within 30 days after vaccination against SARS-CoV-2 in a multinational venous thromboembolism registry
(MDPI, 2022-01-18) Bikdeli, Behnood; Jiménez, David; Demelo Rodríguez, Pablo; Galeano Valle, Francisco; Porras, José Antonio; Barba, Raquel; Ay, Cihan; Maly, Radovan; Braester, Andrei; Imbalzano, Egidio; Rosa, Vladimir; Lecumberri, Ramón; Siniscalchi, Carmine; Fidalgo, Ángeles; Ortiz Serrano, Salvador; Monreal, Manuel; Departamento de Economía Aplicada; Facultad de Ciencias Económicas y Empresariales
Background: Venous thromboembolism (VTE)—including deep vein thrombosis, pulmonary embolism, and cerebral venous sinus thrombosis (CVST)—may occur early after vaccination against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We sought to describe the site, clinical characteristics, and outcomes of VTE after vaccination against SARS-CoV-2. Methods: In a prospective study using the Registro Informatizado de Enfermedad TromboEmbólica (RIETE) platform, patients with VTE 4–30 days after vaccination against SARS-CoV-2 (1 February 2021 through 30 April 2021) were included. VTE patients recruited from the same centers into RIETE in the same months in 2018–2019 were selected as the reference group. All-cause mortality and major bleeding were the main study outcomes. Results: As of 30 April 2020, 102 patients with post-vaccination VTEs had been identified (28 after adenovirus-based vaccination [ChAdOx1 nCov-19; AstraZeneca] and 74 after mRNA-based vaccination [mRNA-1273; Moderna, and BNT162b2; Pfizer]). Compared with 911 historical controls, patients with VTE after adenovirus-based vaccination more frequently had CVST (10.7% vs. 0.4%, p < 0.001) or thrombosis at multiple sites (17.9% vs. 1.3%, p < 0.001), more frequently had thrombocytopenia (40.7% vs. 14.7%, p < 0.001), and had higher 14-day mortality (14.3% vs. 0.7%; odds ratio [OR]: 25.1; 95% confidence interval [CI]: 6.7–94.9) and major bleeding rates (10.3% vs. 1.0%, OR: 12.03, 95% CI: 3.07–47.13). The site of thrombosis, accompanying thrombocytopenia, and 14-day mortality rates were not significantly different for patients with VTE after mRNA-based vaccination, compared with historical controls. Conclusions: Compared with historical controls, VTE after adenovirus-based vaccination against SARS-CoV-2 is accompanied by thrombocytopenia, occurs in unusual sites, and is associated with worse clinical outcomes
Situaciones de necesidad y comunidad de peligro
(Universidad Externado de Colombia, 2022-03-18) Cantard Vanni, Nicolás; Facultad de Derecho; Departamento de Derecho Público y Filosofía Jurídica
En el artículo se analiza la situación derivada de los casos conocidos como “derribo de aviones”, pero que puede ser extendida a otros casos semejantes que genéricamente podríamos conceptualizar como de comunidad de peligro, y cuya característica viene dada por la concurrencia de un peligro para dos o más bienes jurídicos que no pueden ser salvados conjuntamente y que si nada se hiciese, todos ellos se verían afectados. El tratamiento que la doctrina mayoritaria ha dado a la cuestión se muestra insuficiente, tanto desde un aspecto dogmático como político-criminal, generando una incertidumbre que se pone de manifiesto en las diferentes miradas que sobre la cuestión tienen el poder político y la jurisprudencia. Aquí se pretende superar ese estado de incertidumbre, aportando una solución con base en criterios materiales, no consecuencialistas, respetuosos de las garantías del Estado de derecho
Left atrial strain predicts stroke recurrence and death in patients with cryptogenic stroke
(Elsevier, 2023-10-25) Vera Sainz, Alberto; Cecconi, Alberto; Ximénez Carrillo, Álvaro; Ramos, Carmen; Martínez Vives, Pablo; López Melgar, Beatriz; Sanz García, Ancor; Ortega, Guillermo; Aguirre, Clara; Montes, Álvaro; Vivancos Mora, José Aurelio; Jiménez Borreguero, Luis Jesús; Alfonso Manterola, Fernando; Departamento de Medicina; Facultad de Medicina
Left atrial strain (LAS) has been widely studied as a predictor of atrial fibrillation (AF) after cryptogenic stroke (CS). However, the evidence about its prognostic role in terms of stroke recurrence and death in this setting remains scarce. A total of 92 consecutive patients with ischemic stroke or transient ischemic attack with ABCD2 scale ≥4 of unknown etiology were prospectively recruited. Echocardiography, including LAS was performed during admission. The primary outcome measure was the composite of stroke recurrence or death. The mean age was 77.5 ± 7.7, and 58% of patients were female. After a median follow up of 28 months, the primary outcome measure occurred in 15 patients (16%). The primary outcome was more frequent in patients with diabetes (53% vs 21%, p = 0.02), chronic kidney disease (33% vs 10%, p = 0.034), and a history of heart failure (13% vs 0%, p = 0.025). LAS reservoir (LASr) and LAS conduit (LAScd) were lower in patients developing the primary outcome (21% ± 7% vs 28.8% ± 11%, p = 0.017 and 7.7% ± 3.9% vs 13.7% ± 7%, p = 0.007, respectively). On multivariate analysis, LASr (hazard ratio 0.9, 95% confidence interval 0.85 to 0.99, p = 0.048) and diabetes (hazard ratio 3.3, 95% confidence interval 1.03 to 10.4, p = 0.045) were associated with stroke recurrence or all-cause death after CS. On the log-rank test (using the discriminatory cut-off value of LASr <23%), LASr (p = 0.009) was associated with higher risk of the primary outcome. In conclusion, lower values of the LAS reservoir were associated with a higher risk of stroke recurrence or death after CS. LAS may identify patients at higher risk of thromboembolism and stress conditions
Assessment of 1-hour postload plasma glucose, the metabolic syndrome, and the finish diabetes risk score in the prediction of type 2 diabetes
(Elsevier, 2024-09-25) Lizarzaburu Robles, Juan Carlos; Garro Mendiola, Aloso; Lazo Porras, María; Galdón Sanz-Pastor, Alba; Vento, Flor; Lorenzo González, Óscar; Departamento de Medicina; Facultad de Medicina
Objective To compare the 1-hour postload glucose (1h-PG) value of an oral glucose tolerance test (OGTT) with the metabolic syndrome (MetS) and the Finish Diabetes Risk Score (FINDRISC) in patients with impaired fasting glucose (IFG) to predict type 2 diabetes mellitus (T2DM). Methods A cohort study was conducted in patients at a general hospital in Lima, Perú. An OGTT was performed in subjects with IFG who were followed-up for 7 years for T2DM development. The exposure variables were 1h-PG ≥ 155 mg/dL, MetS, and a FINDRISC ≥ 13 points, and the outcome was the presence of T2DM. The relative risk, confidence interval, and area under the curve (AUROC) were also estimated. Results Among 324 subjects with IFG, 218 completed the 7-year follow-up. The mean age was 56.2 ± 11.5 years, 64.0% were woman, and 63.8% were overweight/obese. Of these, 36.8% had 1h-PG ≥ 155 mg/dL and normal glucose tolerance, 66.8% had MetS, and 64.5% had FINDRISC ≥ 13 points. After 7 years, 21.1% of participants developed T2DM, with 68.8% of them who had 1h-PG ≥ 155 mg/dL (P < .001), 62.2% had MetS (P = .013), and 67.9% had FINDRISC ≥ 13 (P = .68). After adjusting by age, sex, and body mass index, the relative risk was 3.52 (1.64-7.54; 95% CI), 1.81 (0.96-3.38; 95% CI), and 1.17 (0.51-2.70; 95% CI) for each exposure variable, respectively. Also, the AUROC was 0.72 (0.60-0.83), 0.63 (0.51-0.75), and 0.51 (0.38-0.63) (P = .01), respectively. Conclusion By performing an OGTT in patients with IFG, an 1h-PG ≥ 155 mg/dL value may be helpful to predict T2DM at 7 years better than the use of MetS or the FINDRISC
A review of meta-argumentative theories of analogy
(Springer, 2025-07-17) Marraud González, Humberto; Agencia Estatal de Investigación; Departamento de Lingüística General, Lógica y Filosofía de la Ciencia, Lenguas Modernas, Teoría de la Literatura y Literatura Comparada, Estudios de Asia Oriental; Facultad de Filosofía y Letras
The key idea of meta-argumentative theories of argument by analogy is that arguments by analogy compare two arguments in order to show whether or not the premises of one of them are adequately connected to its conclusion, and therefore the argument has the logical properties that depend on that connection. The premises-conclusion relationship can be under stood in terms of inferences or in terms of reasons. Consequently I distinguish between an inference-based version and a reasons-based version of the meta-argumentative theory. I argue that an inference-based theory of argument by analogy cannot easily account for neither the usual way of attacking an argument by analogy nor the predominance of counter analogy over direct analogy. A reasons-based meta-argumentative theory does not face the same difficulties because it recognizes the contextual nature of logical evaluation, distinguishing between the parts of an argument (premises and conclusion) and the contextual factors relevant to its logical evaluation (conditions and modifiers). Contextualizing logi cal properties enables us to distinguish between cases in which two arguments are not analogous and cases in which their contexts of evaluation are not analogous. Context-dependence also explains why analogies are used more often to show that an argument is invalid than to show that an argument is valid
Papel del ctDNA en el cáncer colorrectal
(Arán Ediciones, 2024-02) García-Foncillas López, Jesús Miguel; Departamento de Medicina; Facultad de Medicina
La otra conquista de América de Laurent Binet en "Civilizations"
(Universidad de Granada, 2023-05-30) Álvarez de la Cruz, María; Departamento de Filología Francesa; Facultad de Filosofía y Letras
Este trabajo trata de analizar el uso de las formas más clásicas del género histórico y de la escritura histórica que hace Laurent Binet para construir un relato ucrónico y simbólico de lo que hubiera podido ser otro encuentro entre civilizaciones. Al partir de una base ucrónica, se examina la novela Civilizations desde una perspectiva literaria, pero también historicista para deshilar las implicaciones del enfoque de Binet, que sitúa sus giros argumentales en un plano multidimensional, a la par que original en el devenir de la Literatura y la Historia en sí
Opinion dynamics in bounded confidence models with manipulative agents: Moving the Overton window
(Elsevier, 2025-01-25) Bautista Santa-Cruz, Alfredo; Facultad de Ciencias Económicas y Empresariales; Departamento de Análisis Económico: Economía Cuantitativa
This paper focuses on the opinion dynamics under the influence of manipulative agents. This type of agents is characterized by the fact that their opinions follow a trajectory that does not respond to the dynamics of the model, although it does influence the rest of the normal agents. Simulation has been implemented to study how one manipulative group modifies the natural dynamics of some opinion models of bounded confidence. It is studied what strategies based on the number of manipulative agents and their common opinion trajectory can be carried out by a manipulative group to influence normal agents and attract them to their opinions. In certain weighted models, some effects are observed in which normal agents move in the opposite direction to the manipulator group. Moreover, the conditions which ensure the influence of a manipulative group on a group of normal agents over time are also established for the Hegselmann–Krause model
Configuración estructural y significado de los sufijos adjetivales -ivo y -dor
(Universidad de Chile, 2024) Cano Cambronero, Ángeles; Martín García, Josefa; Gobierno de España; Departamento de Filología Española; Facultad de Filosofía y Letras
En este trabajo se muestra que los sufijos adjetivales -ivo y -dor en español, considerados generalmente sinónimos, se especializan a la hora de adjuntarse a una base verbal. En algunos casos, estas son distintas y, en otros muchos, estas son iguales, pero cada sufijo selecciona una lectura verbal diferente. Concretamente, el sufijo -dor selecciona bases y/o lecturas verbales eventivas con un iniciador agentivo; mientras que el sufijo -ivo se especializa para bases y/o lecturas verbales estativas con un iniciador no agentivo. Esta selección determina que los adjetivos sufijados con -dor desarrollen una lectura habitual (hombre madrugador) o episódica (atleta ganador) y que los adjetivos en -ivo, por el contrario, tiendan a una interpretación disposicional (comida nutritiva). Asimismo, los adjetivos en -dor presentan más propiedades verbales que los adjetivos con -ivo, por lo cual pueden heredar los argumentos de la base verbal y admitir modificadores verbales, ambas posibilidades quedan descartadas en los adjetivos derivados con -ivo. Las diferencias semánticas, sintácticas y morfológicas de estos adjetivos se explican a partir de la diferente configuración estructural en la que se generan
Gradación y escalas en la prefijación con sobre-
(Pontificia Universidad Católica de Chile, 2024-09) Martín García, Josefa; Gobierno de España; Departamento de Filología Española; Facultad de Filosofía y Letras
En este artículo se estudian las formaciones prefijadas con sobre- a partir de su significado y de las restricciones en este proceso morfológico. El objetivo es mostrar que la aparente polisemia del prefijo puede explicarse a partir de un significado general común a todas las formaciones. Así, todas las palabras con el prefijo sobre- expresan un punto superior en una escala. La diferencia entre los significados de locación, repetición e intensidad se debe a las distintas escalas lexicalizadas en la base. El análisis unificado que proponemos permite dar cuenta de la relación entre los distintos significados que presentan las formaciones y entre las palabras prefijadas de distinta categoría gramatical
Functional proteomics of colon cancer Consensus Molecular Subtypes
(Springer Nature, 2024-03-14) Feliú Batlle, Jaime; Gámez Pozo, Angelo; Martínez Pérez, Daniel; Pérez Wert, Pablo; Matamala Luengo, Daniel; Viñal, David; Kunz, Laura; López Vacas, Rocío; Dittmann, Antje; Rodríguez Salas, Nuria; Custodio, Ana; Fresno Vara, Juan Ángel; Trilla Fuertes, Lucía; European Commission; Departamento de Medicina; Facultad de Medicina
Background The Colorectal Cancer Subtyping Consortium established four Consensus Molecular Subtypes (CMS) in colorectal cancer: CMS1 (microsatellite-instability [MSI], Immune), CMS2 (Canonical, epithelial), CMS3 (Metabolic), and CMS4 (Mesenchymal). However, only MSI tumour patients have seen a change in their disease management in clinical practice. This study aims to characterise the proteome of colon cancer CMS and broaden CMS’s clinical utility. Methods One-hundred fifty-eight paraffin samples from stage II-III colon cancer patients treated with adjuvant chemotherapy were analysed through DIA-based mass-spectrometry proteomics. Results CMS1 exhibited overexpression of immune-related proteins, specifically related to neutrophils, phagocytosis, antimicrobial response, and a glycolytic profile. These findings suggested potential therapeutic strategies involving immunotherapy and glycolytic inhibitors. CMS3 showed overexpression of metabolic proteins. CMS2 displayed a heterogeneous protein profile. Notably, two proteomics subtypes within CMS2, with different protein characteristics and prognoses, were identified. CMS4 emerged as the most distinct group, featuring overexpression of proteins related to angiogenesis, extracellular matrix, focal adhesion, and complement activation. CMS4 showed a high metastatic profile and suggested possible chemoresistance that may explain its worse prognosis. Conclusions DIA proteomics revealed new features for each colon cancer CMS subtype. These findings provide valuable insights into potential therapeutic targets for colorectal cancer subtypes in the future
Assessment of scalable fractionation methodologies to produce concentrated lauric acid from Black Soldier Fly (Hermetia illucens) larvae fat
(MDPI, 2025-02-06) Reyero, Carlota; Hurtado Ribeira, Raúl; Villanueva Bermejo, David; Vázquez de Frutos, Luis; Belinchón Abenójar, Alejandro; Palomar Herrero, José Francisco; Fornari Reale, Tiziana; Martín García, Diana; Ingredientes alimentarios funcionales (EXP C-064); Departamento de Química Física Aplicada; Departamento de Ingeniería Química
In the present study, different methodologies with potential scalability and environmental friendliness, such as winterization, supercritical fluid extraction, and multistage distillation, were evaluated for lauric acid concentration. In all cases, to facilitate fractionation, the transformation of triacylglycerols into free fatty acids or fatty acid ethyl esters was required as a previous step. For the winterization experimental assays, the amount and type of solvent was studied, resulting in a product containing ~65% lauric acid with a recovery of ~81% using a 1:10 oil-to-solvent ratio with hexane. On the other hand, the experimental extraction with supercritical carbon dioxide in a counter current packed column at 55 ◦C, 115 bar, and 70 g CO2/min, resulted in a product composed of ~80% lauric acid as ethyl ester with a recovery of ~85%. Finally, flash and multistage distillation were analysed using process simulation (Aspen Plus V14), demonstrating that this methodology can achieve 80% recovery with high purity (lauric acid: 96.7%; ethyl laurate: 97.4%), but a high vacuum is required to prevent thermal degradation of the product (lauric acid: 0.2 mbar; ethyl laurate: 1.1 mbar). Overall, the employed methodologies proved highly efficient in concentrating lauric acid, yielding a product of commercial interest and high added value.
Predictors of use of direct oral anticoagulants in patients with venous thromboembolism: findings from the Registro Informatizado Enfermedad Tromboembólica registry
(Springer, 2022-11-25) Lorenzo, Alicia; Beroiz, Patricia; Ortiz Serrano, Salvador; Toro, Jorge del; Mazzolai, Lucia; Bura Riviere, Alessandra; Visoná, Adriana; Verhamme, Peter; Micco, Pierpaolo Di; Camporese, Guiseppe; Sancho Bueso, Teresa; Monreal, Manuel; Departamento de Economía Aplicada; Facultad de Ciencias Económicas y Empresariales
Background: Current guidelines recommend the use of direct oral anticoagulants (DOACs) for patients with venous thromboembolism (VTE). However little is known about the use of DOACs in daily practice. Methods: We used the RIETE registry to identify predictors of use of DOACs for initial and/or long-term therapy of VTE based on patient-related factors, institution-related factors or over time. Results: Among 41,678 patients from March 2013 to September 2021, 12,286 (29%) used DOACs: for initial therapy 6,456; for long-term therapy 12,046. On multivariable analysis, independent predictors were: age < 65 years (odds ratio [OR]: 1.30; 95% CI: 1.23–1.38), body weight <50 kg (OR: 0.54; 95% CI: 0.45–0.65) or >120 kg (OR: 0.64; 95% CI: 0.53–0.77), initial VTE presentation as pulmonary embolism (OR: 1.18; 95% CI: 1.13–1.25), recent bleeding (OR: 0.53; 95% CI: 0.45–0.63), renal insufficiency (OR: 0.44; 95% CI: 0.38–0.51), liver cirrhosis (OR: 0.32; 95% CI: 0.20–0.52), thrombocytopenia (OR: 0.40; 95% CI: 0.34–0.49), atrial fibrillation (OR: 1.58; 95% CI: 1.42–1.75) and prior VTE (OR: 1.14; 95% CI: 1.06–1.22). The DOACs were more likely used in other European countries (OR: 8.97; 95% CI: 8.49–9.49), America (OR: 6.35; 95% CI:5.67–7.11) or in other countries of the world (OR: 2.99; 95% CI: 2.70–3.31) than in Spain, and progressively increased from 2013–2015 to 2016–2018 (OR: 2.78; 95% CI: 2.62–2.95) and 2019–2021 (OR: 6.36; 95% CI: 5.95–6.80). Conclusion: In this large multinational VTE registry, variations were observed in the use of DOACs according to patient or country factors, and over time. The safety, costs, and influence of the DOACs on VTE-related outcomes in daily practice warrant further investigation
Findings and challenges in understanding the impacts of human-induced trampling on Antarctic edaphic microbial communities and their recovery potential
(Cambridge University Press, 2024-12-11) Fernández-Martínez, Miguel Ángel; Galbo Cacha, Rosa María; López Archilla, Ana Isabel; Tejedo, Pablo; Garrido-Benavent, Isaac; Ríos, Asunción de los; Benayas del Álamo, Francisco Javier; Agencia Estatal de Investigación; Departamento de Ecología; Facultad de Ciencias
Antarctic terrestrial ecosystems, covering less than 1% of the continent, are under increasing anthropogenic threats, particularly from climate change and tourism. This study focuses on the impact of human trampling on soil microbial communities in Barrientos Island (South Shetlands archipelago), a frequently visited location. Soil samples were collected within and at the edge of two established paths representing varying levels of human disturbance. Physical and chemical analyses revealed significant differences between the paths, potentially creating anaerobic conditions favorable for specific microbial taxa.Thus, microbial communities also differed between the paths. Aerobic heterotrophic taxa were dominant in the less disturbed path, while anaerobic taxa such as Bacteroidetes vadinHA17 thrived in the more compacted path. Although alpha diversity indices did not differ, beta diversity analyses showed notable distinctions, particularly between the paths rather than trampled and untrampled areas. These findings suggest that microbial communities may recover following the stop of human activity, but also that indigenous microbial communities or other overlooked factors may be influencing the recovery potential. This study thus offers a starting point for similar research, as it highlights the need for further investigation to determine whether human trampling or other environmental factors are primarily responsible for these differences
The cold posterior effect indicates underfitting, and cold posteriors represent a fully bayesian method to mitigate it
(TMLR, 2024-08-05) Zhang, Yijie; Wu, Yi-Shan; Ortega Andrés, Luis A.; Masegosa, Andrés R.; Gobierno de España; Aprendizaje Automático (ING EPS-001); Departamento de Ingeniería Informática; Escuela Politécnica Superior
The cold posterior effect (CPE) (Wenzel et al., 2020) in Bayesian deep learning shows that, for posteriors with a temperature T < 1, the resulting posterior predictive could have better performance than the Bayesian posterior (T = 1). As the Bayesian posterior is known to be optimal under perfect model specification, many recent works have studied the presence of CPE as a model misspecification problem, arising from the prior and/or from the likelihood. In this work, we provide a more nuanced understanding of CPE as we show that misspecification leads to CPE only when the resulting Bayesian posterior underfits. In fact, we theoretically show that if there is no underfitting, there is no CPE. Furthermore, we show that these tempered posteriors with T < 1 are indeed proper Bayesian posteriors with a different combination of likelihoods and priors parameterized by T. This observation validates the adjustment of the temperature hyperparameter T as a straightforward approach to mitigate underfitting in the Bayesian posterior. In essence, we show that by fine-tuning the temperature T we implicitly utilize alternative Bayesian posteriors, albeit with less misspecified likelihood and prior distributions. The code for replicating the experiments can be found at https://github.com/pyijiezhang/cpe-underfit
Unidad de conducta y resultados múltiples como concurso «real». Observaciones críticas a los fundamentos del Acuerdo de Pleno del Tribunal Supremo de 2015
(2023-07) Cantard Vanni, Nicolás; Departamento de Derecho Público y Filosofía Jurídica; Facultad de Derecho
El ámbito de la concurrencia delictiva presenta numerosos problemas de difícil solución que, en gran medida, se replican en los distintos ordenamientos de nuestro entorno jurídico. La relevancia que pueda tener el resultado material en la determinación del tipo de concurso es, no obstante, una discusión que se da, con particular intensidad, en el contexto español. En ese sentido, el Tribunal Supremo español ha decidido que cuando mediante una conducta se produzcan múltiples resultados lesivos contra la vida o la integridad física se aplicarán las reglas del concurso real, adhiriéndose así a una posición que ya era sostenida por un importante sector de la doctrina. Aquí, luego de relevar esas posiciones y analizar críticamente cada uno de los argumentos que la sostienen, se mantendrá una visión opuesta: de lege lata es una decisión forzada que genera más problemas que soluciones y de lege ferenda es innecesaria
Los Prolegómenos a la filosofía como género literario en la escuela neoplatónica de Alejandría
(Universitat de València, 2025-05-30) Zamora Calvo, José María; Gobierno de España; Departamento de Filosofía; Facultad de Filosofía y Letras
El programa filosófico de la escuela neoplatónica de Alejandría entre los siglos V y VI se estructura en torno a los Prolegómenos, o introducciones generales a la filosofía, junto con las introducciones a la filosofía de Platón y de Aristóteles. El objetivo de este artículo es analizar el género literario y filosófico de los Prolegómenos a la filosofía conservados, atribuidos a Ammonio, Elías, David y Pseudo-Elías. Las introducciones generales contienen seis definiciones de filosofía extraídas de autores a los que se otorga una autoridad epistémica ―tres atribuidas a Pitágoras, dos a Platón y una a Aristóteles―, y una descripción de la división de la filosofía en teoría y práctica, establecida por Aristóteles. La función de los Prolegómenos estriba en ofrecer una guía hermenéutica a las interpretaciones posteriores, colocándose al comienzo de los comentarios a la Isagoge de Porfirio
¿Qué es el neoplatonismo? Génesis y encrucijadas de una categoría histórica
(Pontificia Universidad Católica del Perú, 2025-08-11) Zamora Calvo, José María; Departamento de Filosofía; Facultad de Filosofía y Letras
En la historiografía filosófica, el uso del término “neoplatonismo” para referirse a la filosofía de Plotino y sus seguidores es relativamente nuevo, surgiendo en 1742 bajo la influencia de Jakob Brucker. Entre 1770 y 1790, se emplea para distinguir esta corriente de la filosofía de Platón, resaltando que el neoplatonismo introduce el “eclecticismo” y el “sectarismo”, rompiendo con el platonismo antiguo. El objetivo de este artículo es abordar el origen del término “neoplatonismo”, en conexión con la corriente consagrada a la búsqueda del Uno, fuente única y trascendente de toda la realidad. La transformación que experimenta el platonismo surge de la identificación del Uno de la segunda parte del Parménides con el Bien del libro VI de la República
«Soy los contados libros»: propuesta del libro como símbolo en la poesía de madurez de Borges
(UAM Ediciones, 2025-09-22) Ferrera Lagoa, Aldar; Departamento de Filología Española; Facultad de Filosofía y Letras
El universo poético de Jorge Luis Borges ha sido estudiado con base en los símbolos más usuales de su obra. En este trabajo se realiza un estudio semántico de su poesía de madurez para determinar la existencia del libro como símbolo en la poesía borgesiana. Se estudia su amplia presencia textual, así como su contexto poético y su aportación al sentido del poema, para llegar a la conclusión de que el libro es, para Borges, un símbolo del conocimiento del mundo y del paso del tiempo con diferentes connotaciones en función del poema
Jerarquía administrativa, acceso a la función pública y venalidad de los cargos en derecho romano (siglos IV-VI d. C.)
(Universidad Externado de Colombia, 2025-06) Quintana Orive, Elena; Facultad de Derecho; Departamento de Derecho Privado, Social y Económico
La centralización basada en el principio de jerarquía, el cual implica un deber de obediencia de los funcionarios inferiores hacia los superiores, es una de las características de la Administración romana de los siglos IV a VI d. C. La legislación de esta época reguló la promoción y ascenso de los funcionarios públicos dando prioridad a la antigüedad y a los méritos en el servicio para acceder a un cargo público. Pese a ello, se tuvieron que publicar numerosas leyes en las que se prohibía y se castigaba el suffragium (tráfico de influencias), en un intento por moralizar la función pública y mejorar su rendimiento

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