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Synthesis, cytotoxicity, DNA interaction and cell cycle studies of trans-diiodophosphine Pt(ii) complexes
dc.contributor.author | Medrano, Angeles | |
dc.contributor.author | Dennis, Stephen M. | |
dc.contributor.author | Álvarez-Valdés Olaguibel, María Desamparados | |
dc.contributor.author | Perles, Josefina | |
dc.contributor.author | McGregor Mason, Tracey | |
dc.contributor.author | Gómez Quiroga, Adoración | |
dc.contributor.other | UAM. Departamento de Química Inorgánica | es_ES |
dc.date.accessioned | 2016-09-12T16:24:01Z | |
dc.date.available | 2016-09-12T16:24:01Z | |
dc.date.issued | 2015-02-28 | |
dc.identifier.citation | Dalton Transactions 44.8 (2015): 3557-3562 | en_US |
dc.identifier.issn | 1477-9226 (print) | es_ES |
dc.identifier.issn | 1477-9234 (online) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10486/672905 | |
dc.description.abstract | Platinum complexes, bearing aliphatic amines and phosphine ligands in trans configuration with iodide as leaving groups, are synthesized and characterized. The crystal structure of trans-PtI2(isopropylamine)(PPh3) is reported. The complex bearing isopropylamine is demonstrated to be the best candidate as its cytotoxic activity is comparable to or better than cisplatin. A remarkably higher interaction of the complexes with DNA is reported as compared to the parent chlorido series. Cell cycle studies of the complexes in six human cell lines are performed and also compared with the previous series | en_US |
dc.description.sponsorship | The Spanish Ministerio de Economia y Competitividad has supported this work with the grant: SAF2012-34424. This work was also supported by a School of the Sciences, Stevenson University Seed Grant | en_US |
dc.format.extent | 6 pag. | es_ES |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | Royal Society of Chemistry | en_US |
dc.relation.ispartof | Dalton Transactions | en_US |
dc.rights | © The Royal Society of Chemistry 2015 | en_US |
dc.subject.other | Cell culture | en_US |
dc.subject.other | Complexation | en_US |
dc.subject.other | Crystal structure | en_US |
dc.subject.other | Cytotoxicity | en_US |
dc.subject.other | Ligands | en_US |
dc.subject.other | Phosphorus compounds | en_US |
dc.subject.other | Platinum | en_US |
dc.subject.other | Platinum compounds | en_US |
dc.title | Synthesis, cytotoxicity, DNA interaction and cell cycle studies of trans-diiodophosphine Pt(ii) complexes | en_US |
dc.type | article | en |
dc.subject.eciencia | Química | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1039/c4dt02392g | es_ES |
dc.identifier.doi | 10.1039/c4dt02392g | es_ES |
dc.identifier.publicationfirstpage | 3557 | es_ES |
dc.identifier.publicationissue | 8 | es_ES |
dc.identifier.publicationlastpage | 3562 | es_ES |
dc.identifier.publicationvolume | 44 | es_ES |
dc.relation.projectID | Gobierno de España. SAF2012-34424 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.rights.accessRights | openAccess | en |
dc.authorUAM | Perles Hernáez, Josefina (281166) | |
dc.facultadUAM | Facultad de Ciencias |