Characteristics and prognosis of COVID-19 in patients with COPD
Entity
UAM. Departamento de MedicinaPublisher
MDPIDate
2020-10-12Citation
10.3390/jcm9103259
Journal of Clinical Medicine 9 (2020): 3259
ISSN
2077-0383DOI
10.3390/jcm9103259Funded by
Grant COVID-19 UAH 2019/00003/016/001/005 from Alcalá UniversityEditor's Version
https://doi.org/ doi:10.3390/jcm9103259Subjects
COPD; COVID-19; prevalence; prognosis; MedicinaRights
© 2020 by the authorsAbstract
Patients with Chronic Obstructive Pulmonary Disease (COPD) have a higher prevalence
of coronary ischemia and other factors that put them at risk for COVID-19-related complications.
We aimed to explore the impact of COVID-19 in a large population-based sample of patients with
COPD in Castilla-La Mancha, Spain. We analyzed clinical data in electronic health records from
1 January to 10 May 2020 by using Natural Language Processing through the SAVANA Manager®
clinical platform. Out of 31,633 COPD patients, 793 had a diagnosis of COVID-19. The proportion
of patients with COVID-19 in the COPD population (2.51%; 95% CI 2.33–2.68) was significantly
higher than in the general population aged >40 years (1.16%; 95% CI 1.14–1.18); p < 0.001. Compared
with COPD-free individuals, COPD patients with COVID-19 showed significantly poorer disease
prognosis, as evaluated by hospitalizations (31.1% vs. 39.8%: OR 1.57; 95% CI 1.14–1.18) and mortality
(3.4% vs. 9.3%: OR 2.93; 95% CI 2.27–3.79). Patients with COPD and COVID-19 were significantly
older (75 vs. 66 years), predominantly male (83% vs. 17%), smoked more frequently, and had more
comorbidities than their non-COPD counterparts. Pneumonia was the most common diagnosis
among COPD patients hospitalized due to COVID-19 (59%); 19% of patients showed pulmonary
infiltrates suggestive of pneumonia and heart failure. Mortality in COPD patients with COVID-19 was
associated with older age and prevalence of heart failure (p < 0.05). COPD patients with COVID-19
showed higher rates of hospitalization and mortality, mainly associated with pneumonia. This clinical
profile is different from exacerbations caused by other respiratory viruses in the winter season
Files in this item
Google Scholar:Graziani, Desirée
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Soriano, Joan B.
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Río Bermudez, Carlos del
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Morena, Diego
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Díaz, Teresa
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Castillo, María
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Alonso, Miguel
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Ancochea Bermúdez, Julio
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Lumbreras, Sara
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Izquierdo, José Luis
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