Pregnancy-associated plasma protein (PAPP)-A2 in physiology and disease
Entity
UAM. Departamento de PediatríaPublisher
MPIDDate
2021-12-18Citation
10.3390/cells10123576
Cells 10.12 (2021): 3576
ISSN
2073-4409DOI
10.3390/cells10123576Funded by
This research was funded by the Spanish Ministry of Science and Innovation with the help of European FEDER funding (FIS PI19/00166 and PI19/00343), Ministerio de Economía y Competitividad (BFU 2017-82565-C2-1-R) and the Network Center for Biomedical Research on Obesity and Nutrition (CIBEROBN) Instituto Carlos III. S.G.-C. was supported by CIBEROBNProject
Gobierno de España. PI19/00166; Gobierno de España. PI19/00343Subjects
Growth hormone axis; IGF1; IGF2; IGFBPs; PAPP-A; PAPP-A2; STC1; STC2; MedicinaRights
© 2021 by the authorsAbstract
The growth hormone (GH)/insulin-like growth factor (IGF) axis plays fundamental roles during development, maturation, and aging. Members of this axis, composed of various ligands, receptors, and binding proteins, are regulated in a tissue-and time-specific manner that requires precise control that is not completely understood. Some of the most recent advances in understanding the implications of this axis in human growth are derived from the identifications of new mutations in the gene encoding the pregnancy-associated plasma protein PAPP-A2 protease that liberates IGFs from their carrier proteins in a selective manner to allow binding to the IGF receptor 1. The identification of three nonrelated families with mutations in the PAPP-A2 gene has shed light on how this protease affects human physiology. This review summarizes our understanding of the implications of PAPP-A2 in growth physiology, obtained from studies in genetically modified animal models and the PAPP-A2 deficient patients known to date.
Files in this item
Google Scholar:Barrios, Vicente
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Chowen, Julie A.
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Martín-Rivada, Álvaro
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Guerra-Cantera, Santiago
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Pozo Román, Jesús
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Yakar, Shoshana
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Rosenfeld, Ron G.
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Pérez-Jurado, Luis A.
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Suárez, Juan
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Argente Oliver, Jesús
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