dc.contributor.author | Truchado-García, Marta | |
dc.contributor.author | Perry, Kimberly J. | |
dc.contributor.author | Cavodeassi, Florencia | |
dc.contributor.author | Kenny, Nathan J. | |
dc.contributor.author | Henry, Jonathan Q. | |
dc.contributor.author | Grande Pardo, María Cristina | |
dc.contributor.other | UAM. Departamento de Biología | es_ES |
dc.date.accessioned | 2023-03-16T09:15:04Z | |
dc.date.available | 2023-03-16T09:15:04Z | |
dc.date.issued | 2023-02-03 | |
dc.identifier.citation | Molecular biology and evolution 40.2 (2023): msac270 | es_ES |
dc.identifier.issn | 0737-4038 (print) | es_ES |
dc.identifier.issn | 1537-1719 (online) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10486/706667 | |
dc.description | This is a pre-copyedited, author-produced PDF of an article accepted for publication in Molecular biology and evolution following peer review. The version of record Molecular biology and evolution 40.2 (2023): msac270
is available online at: https://academic.oup.com/search-results?page=1&q=10.1093%2Fmolbev%2Fmsac270&fl_SiteID=191&SearchSourceType=1&allJournals=1 | es_ES |
dc.description.abstract | Asymmetries are essential for proper organization and function of organ systems. Genetic studies in bilaterians have shown signaling through the Nodal/Smad2 pathway plays a key, conserved role in the establishment of body asymmetries. Although the main molecular players in the network for the establishment of left-right asymmetry (LRA) have been deeply described in deuterostomes, little is known about the regulation of Nodal signaling in spiralians. Here, we identified orthologs of the egf-cfc gene, a master regulator of the Nodal pathway in vertebrates, in several invertebrate species, which includes the first evidence of its presence in non-deuterostomes. Our functional experiments indicate that despite being present, egf-cfc does not play a role in the establishment of LRA in gastropods. However, experiments in zebrafish suggest that a single amino acid mutation in the egf-cfc gene in at least the common ancestor of chordates was the necessary step to induce a gain of function in LRA regulation. This study shows that the egf-cfc gene likely appeared in the ancestors of deuterostomes and "protostomes", before being adopted as a mechanism to regulate the Nodal pathway and the establishment of LRA in some lineages of deuterostomes | es_ES |
dc.format.extent | 15 pag. | es_ES |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Oxford University Press | es_ES |
dc.relation.ispartof | Molecular biology and evolution | es_ES |
dc.rights | © The Author(s) 2022. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution | es_ES |
dc.subject.other | EGF-CFC | es_ES |
dc.subject.other | EvoDevo | es_ES |
dc.subject.other | Nodal | es_ES |
dc.subject.other | Spiralia | es_ES |
dc.subject.other | zebrafish | es_ES |
dc.subject.other | Crepidula Fornicata | es_ES |
dc.subject.other | Cripto | es_ES |
dc.subject.other | Gene Expression Pattern | es_ES |
dc.subject.other | Left-Right Asymmetry | es_ES |
dc.title | A small change with a twist ending: a single residue in EGF-CFC drives bilaterian asymmetry | es_ES |
dc.type | article | es_ES |
dc.subject.eciencia | Biología y Biomedicina / Biología | es_ES |
dc.relation.publisherversion | https://doi.org/10.1093/molbev/msac270 | es_ES |
dc.identifier.doi | 10.1093/molbev/msac270 | es_ES |
dc.identifier.publicationfirstpage | msac270-1 | es_ES |
dc.identifier.publicationissue | 2 | es_ES |
dc.identifier.publicationlastpage | msac270-15 | es_ES |
dc.identifier.publicationvolume | 40 | es_ES |
dc.relation.projectID | Gobierno de España. CGL2011-29916 | es_ES |
dc.relation.projectID | Gobierno de España. PID2019-104812GB-I00 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.rights.cc | Reconocimiento – NoComercial | es_ES |
dc.rights.accessRights | openAccess | es_ES |
dc.facultadUAM | Facultad de Ciencias | es_ES |