dc.contributor.author | Pastor-Fernández, Andrés | |
dc.contributor.author | Bertos, Antonio R. | |
dc.contributor.author | Sierra-Ramírez, Arantzazu | |
dc.contributor.author | Moral Salmoral, Javier de | |
dc.contributor.author | Merino, Javier | |
dc.contributor.author | de Ávila, Ana I. | |
dc.contributor.author | Olagüe, Cristina | |
dc.contributor.author | Villares, Ricardo | |
dc.contributor.author | González-Aseguinolaza, Gloria | |
dc.contributor.author | Rodríguez, María Ángeles | |
dc.contributor.author | Fresno Escudero, Manuel | |
dc.contributor.author | Gironés Pujol, Nuria | |
dc.contributor.author | Bustos, Matilde | |
dc.contributor.author | Smerdou, Cristian | |
dc.contributor.author | Fernandez-Marcos, Pablo Jose | |
dc.contributor.author | von Kobbe, Cayetano | |
dc.contributor.other | UAM. Departamento de Biología Molecular | es_ES |
dc.date.accessioned | 2023-03-22T12:23:01Z | |
dc.date.available | 2023-03-22T12:23:01Z | |
dc.date.issued | 2023-01-26 | |
dc.identifier.citation | Aging Cell 22.3 (2023): e13771 | es_ES |
dc.identifier.issn | 1474-9718 (print) | es_ES |
dc.identifier.issn | 1474-9726 (online) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10486/706756 | |
dc.description.abstract | The enormous societal impact of the ongoing COVID-19 pandemic has been particularly harsh for some social groups, such as the elderly. Recently, it has been suggested that senescent cells could play a central role in pathogenesis by exacerbating the pro-inflammatory immune response against SARS-CoV-2. Therefore, the selective clearance of senescent cells by senolytic drugs may be useful as a therapy to ameliorate the symptoms of COVID-19 in some cases. Using the established COVID-19 murine model K18-hACE2, we demonstrated that a combination of the senolytics dasatinib and quercetin (D/Q) significantly reduced SARS-CoV-2-related mortality, delayed its onset, and reduced the number of other clinical symptoms. The increase in senescent markers that we detected in the lungs in response to SARS-CoV-2 may be related to the post-COVID-19 sequelae described to date. These results place senescent cells as central targets for the treatment of COVID-19, and make D/Q a new and promising therapeutic tool | es_ES |
dc.format.extent | 15 pag. | es_ES |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley Open Access | es_ES |
dc.relation.ispartof | Aging Cell | es_ES |
dc.rights | © 2023 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. | es_ES |
dc.subject.other | COVID-19 | es_ES |
dc.subject.other | SARS-CoV-2 | es_ES |
dc.subject.other | Cellular Senescence | es_ES |
dc.subject.other | Senolytics | es_ES |
dc.subject.other | Survival | es_ES |
dc.title | Treatment with the senolytics dasatinib/quercetin reduces SARS-CoV-2-related mortality in mice | es_ES |
dc.type | article | es_ES |
dc.subject.eciencia | Biología y Biomedicina / Biología | es_ES |
dc.relation.publisherversion | https://doi.org/10.1111/acel.13771 | es_ES |
dc.identifier.doi | 10.1111/acel.13771 | es_ES |
dc.identifier.publicationfirstpage | e13771-1 | es_ES |
dc.identifier.publicationissue | 3 | es_ES |
dc.identifier.publicationlastpage | e13771-15 | es_ES |
dc.identifier.publicationvolume | 22 | es_ES |
dc.relation.projectID | Gobierno de España. SAF2017-85766-R | es_ES |
dc.relation.projectID | Gobierno de España. PID2020-114077RB-I00 | es_ES |
dc.relation.projectID | Gobierno de España. PID2020-113888RB-I00 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.rights.cc | Reconocimiento | es_ES |
dc.rights.accessRights | openAccess | es_ES |
dc.facultadUAM | Facultad de Ciencias | es_ES |
dc.institutoUAM | Centro de Biología Molecular Severo Ochoa (CBMSO) | es_ES |