Higher mortality of hospitalized haematologic patients with COVID-19 compared to non-haematologic is driven by thrombotic complications and development of ARDS: An age-matched cohorts study
Entity
UAM. Departamento de MedicinaPublisher
ElsevierDate
2022-02-15Citation
10.1016/j.clinpr.2022.100137
Clinical Infection in Practice 13 (2022): 100137
ISSN
2590-1702 (online)DOI
10.1016/j.clinpr.2022.100137Editor's Version
https://doi.org/10.1016/j.clinpr.2022.100137Subjects
COVID-19; Haematologic; Mortality; Outcome; MedicinaRights
© 2022 The Author(s)Esta obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial-SinObraDerivada 4.0 Internacional.
Abstract
Background and Objectives: The characteristics of COVID-19 in haematologic patients compared to non-haematologic patients have seldom been analyzed. Our aim was to analyze whether there are differences in clinical characteristics and outcome of haematologic patients with COVID-19 as compared to non-haematologic. Patients and methods: Retrospective cohort study in 2 University hospitals of patients admitted with laboratory-confirmed COVID-19 included in the SEMICOVID19 database. The cohort with underlying haematologic disease was compared to a cohort of age and date-of-COVID-19-matched controls without haematologic disease (1:2). Results: 71 cases and 142 controls were included from March-May 2020. Twenty (28.1%) had received recent chemotherapy. Twelve (16.9%) were stem cell transplant recipients (SCT). Eleven (15.5%) were neutropenic concurrently with COVID-19 diagnosis. Haematologic patients presented ARDS (58.5 vs 20.7%, p = 0.0001), thrombotic complications (15.7 vs 2.1%, p = 0.002), DIC (5.7 vs 0.0%, p = 0.011), heart failure (14.3 vs 4.9%, p = 0.029) and required ICU admission (15.5 vs 2.8%, p = 0.001), MV (14.1% vs 2.1%, p 0.001), steroid (64.8 vs 33.1%, p = 0.0001), tocilizumab (33.8 vs 8.5%, p = 0.0001) or anakinra treatment (9.9% vs 0%, p = 0.0001) more often. In-hospital mortality was significantly higher (38.0% vs 18.3%, p = 0.002). Conclusions: Our results suggest COVID-19 has worse outcomes in haematologic patients than in non-haematologic, independently of age, and that the development of ARDS and thrombotic complications drive the higher in-hospital mortality
Files in this item
Google Scholar:Fernández-Cruz, Ana
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Puyuelo, Alba
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Núñez Martín-Buitrago, Lucía
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Sánchez-Chica, Enrique
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Díaz-Pedroche, Carmen
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Ayala, Rosa
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Lizasoain, Manuel
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Duarte Palomino, Rafael
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Lumbreras, Carlos
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Vargas Núñez, Juan Antonio
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