Tumor P70S6K hyperactivation is inversely associated with tumor-infiltrating lymphocytes in triple-negative breast cancer
Entity
UAM. Departamento de MedicinaPublisher
Springer NatureDate
2022-12-12Citation
10.1007/s12094-022-03006-3
Clinical and Translational Oncology 25 (2023): 1124-1131
ISSN
1699-048X (print); 1699-3055 (online)DOI
10.1007/s12094-022-03006-3Funded by
The project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 893597. RC is a recipient of the ISCIII grants: PI17/01865 and PI20/01458. MQF is a recipient of the following Grants: AES-PI19/00454 funded by the ISCIII and co-funded by the European Regional Development Fund (ERDF) and B2017/BMD3733 (Immunothercan-CM)—Call for Coordinated Research Groups from Madrid Region—Madrid Regional Government—ERDF funds. The study was also funded by CRIS Contra el Cancer FoundationProject
info:eu-repo/grantAgreement/EC/H2020/893597; Gobierno de España. PI17/01865; Gobierno de España. PI19/00454; Comunidad de Madrid. B2017/BMD3733Editor's Version
https://doi.org/10.1007/s12094-022-03006-3Subjects
B cells; P70S6K; T cells; TIL; TNBC; MedicinaRights
© The Author(s) 2022Abstract
Purpose: Triple-negative breast cancer (TNBC) is characterized by large heterogeneity and relative lack of available targeted therapies. To find therapeutic strategies for distinct patients with TNBC, several approaches have been used for TNBC clustering, including recently immune and phosphoproteomic patterns. Based on 70-kDa ribosomal protein S6 kinase (P70S6K)-TNBC clustering, the current study explores the immune profiling in TNBC tumors. Methods: Stromal tumor-infiltrating lymphocytes (sTILs) were evaluated in human TNBC tumor samples. Furthermore, immunohistochemistry staining for CD8, CD4, Foxp3, and CD20 was performed in tissue microarrays (TMA) sections. Results: Histological analysis showed decreased sTILs, CD20+ cells, and CD8+/CD4+ ratio in high phosphorylated P70S6K (p-P70S6K) tumors. Moreover, p-P70S6K score was directly correlated with CD4+ and Foxp3+ T cells, while it was inversely correlated with CD8+/CD4+ and CD8+/Foxp3+ ratios. Conclusion: sTIL infiltration and lymphocyte profiling vary in the context of hyperactivation of P70S6K in TNBC tumors
Files in this item
Google Scholar:Jimeno, Rebeca
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Mouron, Silvana
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Salgado, Roberto
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Loi, Sherene
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Pérez-Mies, Belén
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Sánchez-Bayona, Rodrigo
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Manso, Luis
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Martínez, Mario
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Garrido-García, Ana
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Serrano-Pardo, Rosario
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Colomer Bosch, Ramón
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Quintela Fandiño, Miguel Ángel
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