Instantaneous In Vivo Imaging of Acute Myocardial Infarct by NIR-II Luminescent Nanodots
Author
Mateos, Sergio; Lifante Cañavate, José; Li, Chunyan; Ximendes, Erving Clayton; Muñoz-Ortiz, Tamara; Yao, Jingke; de la Fuente-Fernández, María; García Villalón, Ángel Luis; Granado, Miriam; Zabala Gutierrez, Irene; Rubio-Retama, Jorge; Jaque García, Daniel; Ortgies, Dirk Horst; Fernández Monsalve, NuriaEntity
UAM. Departamento de Física de Materiales; UAM. Departamento de FisiologíaPublisher
WileyDate
2020-06-17Citation
Small 16.29 (2020): 1907171ISSN
1613-6810Funded by
Support from the Ministerio de Economía y Competitividad de España (MAT2016-75362-C3-1-R) and (MAT2017-83111R), from the Instituto de Salud Carlos III (PI16/00812), and from the Comunidad Autónoma de Madrid (B2017/BMD-3867RENIMCM) is acknowledged. The European Structural and Investment funds, which co-financed this work, is also acknowledged. Additionally, the investigation was supported by the European Commission Horizon 2020 project NanoTBTech, the Fundación para la Investigación Biomédica del Hospital Universitario Ramón y Cajal project IMP18_38 (2018/0265), and also by COST action CM1403. D.H.O. is grateful to the Instituto de Salud Carlos III for a Sara Borrell scholarship (No. CD17/00210)Project
Gobierno de España. MAT2016-75362-C3-1-R; Gobierno de España. MAT2017-83111R; Comunidad de Madrid. B2017/BMD-3867/RENIM-CMEditor's Version
https://doi.org/10.1002/smll.201907171Subjects
Near-infrared imaging; Myocardial infarct; Luminescence; Nanoparticles; Ag2S; Biología y Biomedicina / Biología; FísicaRights
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimAbstract
Fast and precise localization of ischemic tissues in the myocardium after an acute infarct is required by clinicians as the first step toward accurate and efficient treatment. Nowadays, diagnosis of a heart attack at early times is based on biochemical blood analysis (detection of cardiac enzymes) or by ultrasound-assisted imaging. Alternative approaches are investigated to overcome the limitations of these classical techniques (time-consuming procedures or low spatial resolution). As occurs in many other fields of biomedicine, cardiological preclinical imaging can also benefit from the fast development of nanotechnology. Indeed, bio-functionalized near-infrared-emitting nanoparticles are herein used for in vivo imaging of the heart after an acute myocardial infarct. Taking advantage of the superior acquisition speed of near-infrared fluorescence imaging, and of the efficient selective targeting of the near-infrared-emitting nanoparticles, in vivo images of the infarcted heart are obtained only a few minutes after the acute infarction event. This work opens an avenue toward cost-effective, fast, and accurate in vivo imaging of the ischemic myocardium after an acute infarct
Files in this item
Google Scholar:Mateos, Sergio
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Lifante Cañavate, José
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Li, Chunyan
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Ximendes, Erving Clayton
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Muñoz-Ortiz, Tamara
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Yao, Jingke
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de la Fuente-Fernández, María
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García Villalón, Ángel Luis
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Granado, Miriam
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Zabala Gutierrez, Irene
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Rubio-Retama, Jorge
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Jaque García, Daniel
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Ortgies, Dirk Horst
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Fernández Monsalve, Nuria
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