A colloidal singularity reveals the crucial role of colloidal stability for nanomaterials in-vitro toxicity testing: nZVI-microalgae colloidal system as a case study
Entity
UAM. Departamento de BiologíaPublisher
Public Library of ScienceDate
2014-10-23Citation
10.1371/journal.pone.0109645
Plos One 9.10 (2014): e109645
ISSN
1932-6203 (online)DOI
10.1371/journal.pone.0109645Funded by
This research was supported by the Comunidad de Madrid grants S-0505/AMB/0321 and S-2009/AMB/1511 (Microambiente-CM). The Spanish Ministry of Science and Innovation grants CGL2010-15675 sub-program BOS, and the CTM2008-04239/TECNO, and the Spanish Ministry of Economy and Competitiveness (MINECO) grants CTM2013-45775-C2-1-R, CTM2013-45775-C2-2-R and the US-National Science Foundation, grant number CBET-0853347Project
Comunidad de Madrid. S2009/AMB-1511/MICROAMBIENTE; Comunidad de Madrid. S0505/AMB-0321/MICROAMBIENTESubjects
biological activity; colloid; colloidal stability; in vitro study; microalga; molecular stability; nanotoxicology; physical chemistry; Biología y Biomedicina / BiologíaRights
This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purposeAbstract
Aggregation raises attention in Nanotoxicology due to its methodological implications. Aggregation is a physical symptom of a more general physicochemical condition of colloidal particles, namely, colloidal stability. Colloidal stability is a global indicator of the tendency of a system to reduce its net surface energy, which may be achieved by homo-aggregation or hetero-aggregation, including location at bio-interfaces. However, the role of colloidal stability as a driver of ENM bioactivity has received little consideration thus far. In the present work, which focuses on the toxicity of nanoscaled Fe° nanoparticles (nZVI) towards a model microalga, we demonstrate that colloidal stability is a fundamental driver of ENM bioactivity, comprehensively accounting for otherwise inexplicable differential biological effects. The present work throws light on basic aspects of Nanotoxicology, and reveals a key factor which may reconcile contradictory results on the influence of aggregation in bioactivity of ENMs
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Google Scholar:Gonzalo, Soledad
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Pulido-Reyes, Gerardo
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Fernández Piñas, Francisca
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Bonzongo, Jean Claude
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Leganés Nieto, Francisco
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Rosal, Roberto
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García-Calvo, Eloy
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Rodea-Palomares, Ismael
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