Cathepsin D in a murine model of frontotemporal dementia with parkinsonism-linked to chromosome 17
Entidad
UAM. Departamento de Anatomía, Histología y NeurocienciaEditor
IOS PressFecha de edición
2015-01-01Cita
10.3233/JAD-140456
Journal of Alzheimer's Disease 45.1 (2015): 1-14
ISSN
1387-2877DOI
10.3233/JAD-140456Financiado por
This study was funded by grant from the Spanish Ministry of Health (SAF 2011-24841)Proyecto
Gobierno de España. SAF 2011-24841Versión del editor
http://dx.doi.org/10.3233/JAD-140456Materias
Cathepsin D; FTDP-17; Lysosomal system; Mutated tau; MedicinaNota
The final of publication is available at: http://dx.doi.org/10.3233/JAD-140456Resumen
Tauopathies, such as Alzheimer’s disease (AD) and Frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), are characterized by tau accumulation. This accumulation could result from alterations in tau degradation by either the ubiquitin-proteasome system or the autophagy–lysosomal pathway. To analyze a possible alteration of the autophagy–lysosomal pathway in transgenic mice expressing human tau with three FTDP-17 missense mutations (TauVLW mice), we studied the lysosomal enzyme Cathepsin D. The hippocampi of TauVLW mice, where the human mutant tau accumulates, showed both increased Cathepsin D and partial colocalization of Cathepsin D with human mutant tau. At the ultrastructural level, some multivesicular bodies showed human mutant tau-immunopositive vesicles. This finding could provide insights into the molecular mechanisms of tau degradation in human tauopathies
Lista de ficheros
Google Scholar:Fernández-Montoya, Julia
-
Pérez, Mar
Lista de colecciones del ítem
Registros relacionados
Mostrando ítems relacionados por título, autor, creador y materia.
-
Sporadic colon cancer murine models demonstrate the value of autoantibody detection for preclinical cancer diagnosis
Barderas, Rodrigo; Villar-Vázquez, Roi; Fernández-Acereño, María Jesús; Babel, Ingrid; Peláez-García, Alberto; Torres, Sofía; Casal, J. Ignacio
2013-10-15 -
Murine models for the study of fetal alcohol spectrum disorders: An overview
Almeida, Laura; Andreu-Fernández, Vicente; Navarro-Tapia, Elisabet; Aras-López, Rosa; Serra-Delgado, Mariona; Martínez, Leopoldo; García-Algar, Oscar; Gómez-Roig, María Dolores
2020-07-15