Inflammatory-related clinical and metabolic outcomes in Covid-19 patients
Entidad
UAM. Departamento de MedicinaEditor
Hindawi Ltd.Fecha de edición
2020-11-26Cita
10.1155/2020/2914275
Mediators of Inflammation 2020 (2020): 2914275
ISSN
0962-9351DOI
10.1155/2020/2914275Financiado por
CIBERon Instituto Carlos III in Madrid is credited for institutional support.Versión del editor
https://doi.org/10.1155/2020/2914275Materias
SARS-CoV-2; Inflamatory; Pneumonia; Intensive Care Unit (ICU); MedicinaDerechos
© 2020 Maria Martinez-Urbistondo et al.Resumen
Background. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) infection elicits inflammatory manifestations that relate with a “cytokine storm.” Objective. The aim of this research was to assess the role of circulating interleukin 6 (IL-6) levels and other inflammatory markers in patients with coronavirus disease 2019 (COVID-19) on metabolic functions and accompanying clinical complications. Patients and Methods. A total of 165 patients diagnosed with COVID-19 pneumonia were examined for medical features and inflammatory markers such as blood IL-6, CRP, ferritin, LDH, neutrophil/lymphocyte index (NLI), D-Dimer, and Red Cell Distribution Width (RDW). Regression analyses concerning electronically collected medical data were adjusted by appropriate factors and confounding variables. Results. Plasma IL-6 determinations evidenced a consistent association with hospital stay days, Intensive Care Unit (ICU) admission, and mortality rates. Similar trends were found for other proinflammatory variables, where ferritin and NLI showed a remarkable value as surrogates. Hyperglycaemia and the Charlson Comorbidity Index Score were positively associated with the inflammatory response induced by the SARS-COV-2 infection. An unhealthy lifestyle such as smoking and alcoholic drinks consumption as well as excessive body adiposity influenced inflammatory-related outcomes in the screened patients. Conclusion. IL-6 together with other inflammatory biomarkers accompanied poor clinical and metabolic outcomes in COVID-19-infected patients. IL-6 may result in a suitable proxy to individually categorise patients in order to manage this infectious pandemic.
Lista de ficheros
Google Scholar:Martinez-Urbistondo, Maria
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Mora-Vargas, Alberto
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Expósito-Palomo, Esther
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Castejón, Raquel
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Citores, M. Jesús
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Rosado, Silvia
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de Mendoza, Carmen
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Baños, Isolina
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Fernández-Cruz, Ana
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Daimiel, Lidia
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San-Cristóbal, Rodrigo
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Vargas Núñez, Juan Antonio
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Martinez, J. Alfredo
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